ArticlePlacenta2014
Variation of DNA methylation in candidate age-related targets on the mitochondrial-telomere axis in cord blood and placenta.
Article in Placenta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- A Pilot Study on the Effects of l-Carnitine and Trimethylamine-N-Oxide on Platelet Mitochondrial DNA Methylation and CVD Biomarkers in Aged Women.International journal of molecular sciences · 2020Trial
- Mitochondrial D-Loop Region Methylation Is Not Altered in Children with Autism Spectrum Disorder.Epigenomes · 2026Article
- Optimized bisulfite sequencing analysis reveals the lack of 5-methylcytosine in mammalian mitochondrial DNA.BMC genomics · 2023Article
- Article
- Interplay of Placental DNA Methylation and Maternal Insulin Sensitivity in Pregnancy.Diabetes · 2020Article
- Variability of iodine concentrations in the human placenta.Scientific reports · 2020Article
- Early Biological Aging and Fetal Exposure to High and Low Ambient Temperature: A Birth Cohort Study.Environmental health perspectives · 2019Article
- Association between prenatal particulate air pollution exposure and telomere length in cord blood: Effect modification by fetal sex.Environmental research · 2019Article
- Article
- Environment, susceptibility windows, development, and child health.Current opinion in pediatrics · 2017Review
- Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort.Environmental health perspectives · 2017Article
- Placental mitochondrial DNA and CYP1A1 gene methylation as molecular signatures for tobacco smoke exposure in pregnant women and the relevance for birth weight.Journal of translational medicine · 2017Article
- DNA methylation of candidate genes in peripheral blood from patients with type 2 diabetes or the metabolic syndrome.PloS one · 2017Article
- Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRClinical epigenetics · 2017Article
- Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood.Environment international · 2017Article
- Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies.Neuroscience letters · 2016Review
- CpG methylation patterns of human mitochondrial DNA.Scientific reports · 2016Article
- Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIRONAGE birth cohort study.Epigenetics · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundEpigenetics is tissue-specific and potentially even cell-specific, but little information is available from human reproductive studies about the concordance of DNA methylation patterns in cord blood and placenta, as well as within-placenta variations. We evaluated methylation levels at promoter regions of candidate genes in biological ageing pathways (SIRT1, TP53, PPARG, PPARGC1A, and TFAM), a subtelomeric region (D4Z4) and the mitochondrial genome (MT-RNR1, D-loop).
methodsNinety individuals were randomly chosen from the ENVIRONAGE birth cohort to evaluate methylation concordance between cord blood and placenta using highly quantitative bisulfite-PCR pyrosequencing. In a subset of nineteen individuals, a more extensive sampling scheme was performed to examine within-placenta variation.
resultsThe DNA methylation levels of the subtelomeric region and mitochondrial genome showed concordance between cord blood and placenta with correlation coefficients ranging from r = 0.31 to 0.43, p ≤ 0.005, and also between the maternal and foetal sides of placental tissue (r = 0.53 to 0.72, p ≤ 0.05). For the majority of targets, an agreement in methylation levels between four foetal biopsies was found (with intra-class correlation coefficients ranging from 0.16 to 0.72), indicating small within-placenta variation.
conclusionsThe methylation levels of the subtelomeric region (D4Z4) and mitochondrial genome (MT-RNR1, D-loop) showed concordance between cord blood and placenta, suggesting a common epigenetic signature of these targets between tissues. Concordance was lacking between the other genes that were studied. In placental tissue, methylation patterns of most targets on the mitochondrial-telomere axis were not strongly influenced by sample location.
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