Trial reportBMC psychiatry2014
Sleep disturbance, depression and pain in adults with sickle cell disease.
Trial report in BMC psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00011648 (Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients With Sickle Cell Anemia), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients With Sickle Cell Anemia
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- The Use of Religion in the Management of Depression in Sickle Cell Disease: A Systematic Review.Journal of religion and health · 2020Pooled it
- Acupuncture for chronic pain in adults with sickle cell disease: a mixed-methods pilot study.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2021Trial
- Trial
- Patient-reported outcomes in sickle cell disease and association with clinical and psychosocial factors: Report from the sickle cell disease implementation consortium.American journal of hematology · 2020Trial
- Linking Nonrestorative Sleep and Activity Interference Through Pain Catastrophizing and Pain Severity: An Intraday Process Model Among Individuals With Fibromyalgia.The journal of painTrial
- Integrating primary care for depression management during transition in sickle cell disease: A pre-post feasibility study.British journal of haematology · 2026Article
- Association between comorbid depression, antidepressant adherence, and disease-modifying therapy adherence among Texas Medicaid patients with sickle cell disease.Journal of managed care & specialty pharmacy · 2026Article
- Preliminary Benefits of In-Home Virtual Reality for Chronic Pain in Sickle Cell Disease: Pilot Randomized Trial.Biomedicines · 2026Article
- An Examination of John Henryism in Adults Living with Sickle Cell Disease.Journal of racial and ethnic health disparities · 2025Article
- Restless legs syndrome and ferritin levels in older adults with dementia: a cross-sectional study.Dementia & neuropsychologia · 2025Article
- Recommended measurement protocols for sickle cell disease in the PhenX toolkit: psychosocial factors and social determinants of health.Journal of sickle cell disease · 2025Article
- Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2024Review
- Knowledge and Experience of In-Home Virtual Reality for Chronic Pain in Sickle Cell Disease.The journal of pain · 2024Article
- Epigenetic Aging Associations With Psychoneurological Symptoms and Social Functioning in Adults With Sickle Cell Disease.Biological research for nursing · 2024Article
- Mental health, pain and likelihood of opioid misuse among adults with sickle cell disease.British journal of haematology · 2024Article
- Associations of multimorbidity with body pain, sleep duration, and depression among middle-aged and older adults in China.Health and quality of life outcomes · 2024Article
- Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice.CNS neuroscience & therapeutics · 2024Article
- Burden of Aging: Health Outcomes Among Adolescents and Young Adults With Sickle Cell Disease.HemaSphere · 2023Article
- The relationship between pain and sleep in pediatric sickle cell disease.Pediatric blood & cancer · 2023Article
- Internalizing Symptoms in Adolescents With Sickle Cell Disease.Journal of pediatric psychology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSleep disturbance and depression are commonly encountered in primary care. In sickle cell disease, depression is associated with pain, poor treatment compliance, and lower quality of life. The prevalence of sleep disturbance and its effect upon quality of life in adults with sickle cell disease is unknown. The goal of this study was to determine the prevalence of sleep disturbance and if it is associated with pain and depression in sickle cell disease.
methodsThree hundred twenty eight adults with sickle cell disease enrolled on the Bethesda Sickle Cell Cohort Study were assessed using the Pittsburgh Sleep Quality Index and Beck Depression Inventory II screening measures as a cross-sectional survey. Scores greater than 5 (Pittsburgh Sleep Quality Index) and 16 (Beck Depression Inventory II) defined sleep disturbance and depression, respectively. Clinical and laboratory parameters were also assessed.
resultsThe mean Pittsburgh Sleep Quality Index score was 8.4 (SD ± 4.2) indicating a 71.2% prevalence of sleep disturbance. The mean Beck Depression Inventory II score was 8.0 (SD ± 8.9). Sixty five (20.6%) participants had a score indicating depression, and half of these (10.0%) had thoughts of suicide. Both Pittsburgh Sleep Quality Index and Beck Depression Inventory II scores were significantly correlated (p < .001). The number of days with mild/moderate pain (p = .001) and a history of headaches (p = .005) were independently associated with depression by multivariate regression analysis. Patients with sleep disturbance were older (p = .002), had higher body mass index (p = .011), had more days of pain (p = .003) and more frequent severe acute painful events (emergency room visits and hospitalizations) during the previous 12 months (p < .001).
conclusionsMore than 70 percent of adults with sickle cell disease had sleep disturbance, while 21 percent showed evidence of clinical depression. Sleep disturbance and depression were correlated, and were most common among those with more frequent pain. Providers caring for adults with sickle cell disease and frequent pain should consider screening for these common co-morbidities. Additional study is needed to confirm these findings and to determine if treatments for pain, depression or sleep disturbances will improve quality of life measures in this patient population.
trial registrationClinicalTrials.gov identifier: NCT00011648.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.