Evidence map›Paper›PMID 25047625›Full record

ArticleBiomaterials2014

Discrete microstructural cues for the attenuation of fibrosis following myocardial infarction.

James R Pinney, Kim T Du, Perla Ayala, Qizhi Fang, Richard E Sievers, Patrick Chew, Lawrence Delrosario, Randall J Lee, Tejal A Desai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Micro- and nanoscale biophysical cues for cardiovascular disease therapy.Nanomedicine : nanotechnology, biology, and medicine · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

James R PinneyUC Berkeley - UCSF Graduate Group in Bioengineering, 1700 4th Street, QB3 Byers Hall, Room 203, San Francisco, CA 94158, USA; UCSF Medical Scientist Training Program, 1700 4th Street, QB3 Byers Hall, Room 203, San Francisco, CA 94158, USA.
Kim T DuUCSF Department of Medicine, Cardiovascular Research Institute and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Box 1354, 513 Parnassus Ave, MS Room 1136, San Francisco, CA 94143, USA.
Perla AyalaUC Berkeley - UCSF Graduate Group in Bioengineering, 1700 4th Street, QB3 Byers Hall, Room 203, San Francisco, CA 94158, USA; Beth Israel Deaconess Medical Center, Department of Surgery, Center for Life Science Surgery/BIDMC, 11th Floor, 3 Blackfan Circle, Boston, MA 02115, USA.
Qizhi FangUCSF Department of Medicine, Cardiovascular Research Institute and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Box 1354, 513 Parnassus Ave, MS Room 1136, San Francisco, CA 94143, USA.
Richard E SieversUCSF Department of Medicine, Cardiovascular Research Institute and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Box 1354, 513 Parnassus Ave, MS Room 1136, San Francisco, CA 94143, USA.
Patrick ChewUCSF Bioengineering and Therapeutic Sciences, 1700 4th Street, Byers Hall Room 203, San Francisco, CA 94158, USA.
Lawrence DelrosarioUCSF School of Medicine, 513 Parnassus Ave, MS Room 1136, San Francisco, CA 94143, USA.
Randall J LeeUC Berkeley - UCSF Graduate Group in Bioengineering, 1700 4th Street, QB3 Byers Hall, Room 203, San Francisco, CA 94158, USA; UCSF Department of Medicine, Cardiovascular Research Institute and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Box 1354, 513 Parnassus Ave, MS Room 1136, San Francisco, CA 94143, USA.
Tejal A DesaiUC Berkeley - UCSF Graduate Group in Bioengineering, 1700 4th Street, QB3 Byers Hall, Room 203, San Francisco, CA 94158, USA; UCSF Bioengineering and Therapeutic Sciences, 1700 4th Street, Byers Hall Room 203, San Francisco, CA 94158, USA. Electronic address: tejal.desai@ucsf.edu.
Broad Center · USUniversity of California, Berkeley · USUniversity of California, San Francisco · USUniversity of California San Francisco Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Cardiac Regeneration through Growth Factor Eluting Microrod ScaffoldsR01HL090523 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GOLDSPINK, PAUL H · 2009 to 2013
$1.8M
NHLBI NIH HHS R01 HL090523NIGMS NIH HHS T32 GM007618
6 · The paper itself

Abstract

Chronic fibrosis caused by acute myocardial infarction (MI) leads to increased morbidity and mortality due to cardiac dysfunction. We have developed a therapeutic materials strategy that aims to mitigate myocardial fibrosis by utilizing injectable polymeric microstructures to mechanically alter the microenvironment. Polymeric microstructures were fabricated using photolithographic techniques and studied in a three-dimensional culture model of the fibrotic environment and by direct injection into the infarct zone of adult rats. Here, we show dose-dependent down-regulation of expression of genes associated with the mechanical fibrotic response in the presence of microstructures. Injection of this microstructured material into the infarct zone decreased levels of collagen and TGF-β, increased elastin deposition and vascularization in the infarcted region, and improved functional outcomes after six weeks. Our results demonstrate the efficacy of these discrete anti-fibrotic microstructures and suggest a potential therapeutic materials approach for combatting pathologic fibrosis.

Indexed as

3T3 CellsAnimalsBiocompatible MaterialsCollagenFemaleFibroblastsFibrosisMethacrylatesMiceMicrotechnologyMyocardial InfarctionMyocardiumPolyethylene GlycolsRats, Sprague-DawleyTissue EngineeringBiocompatible MaterialsCollagenMethacrylatespoly(ethylene glycol)-dimethacrylatePolyethylene GlycolsCardiac tissue engineeringCollagenECMFibrosisPhotolithographyPolyethylene glycol dimethacrylate

Identifiers

PMID25047625
PMCPMC4144416
OpenAlexW2020362528

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.