ArticleThe American journal of gastroenterology2014
Alcohol and the risk of Barrett's esophagus: a pooled analysis from the International BEACON Consortium.
Article in The American journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Association Between Alcohol Consumption and the Risk of Barrett's Esophagus: A Meta-Analysis of Observational Studies.Medicine · 2015Pooled it
- Physiologic and molecular effects of alcohol in the esophagus: a narrative review.Annals of esophagus · 2025Article
- The Relationship between Dietary Habits and Gastroesophageal Reflux Disease: A Two-sample Mendelian Randomization Study.Current medicinal chemistry · 2025Article
- Diagnosis and Management of Barrett's Esophagus.Journal of clinical medicine · 2023Review
- Association of educational attainment with esophageal cancer, Barrett's esophagus, and gastroesophageal reflux disease, and the mediating role of modifiable risk factors: A Mendelian randomization study.Frontiers in public health · 2023Article
- Influence of Alcohol Consumption on the Development of Erosive Esophagitis in Both Sexes: A Longitudinal Study.Nutrients · 2022Observational
- Analysis of Barrett's Esophagus and Its Risk Factors: A Cross-Sectional Study of 10,122 Subjects at a Japanese Health Examination Center.Digestion · 2022Article
- The Prevalence of Barrett's Esophagus Among a Saudi Arabian Population.Digestive diseases and sciences · 2021Article
- Global burden and epidemiology of Barrett oesophagus and oesophageal cancer.Nature reviews. Gastroenterology & hepatology · 2021Review
- Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma.PLoS computational biology · 2021Article
- Prevalence and Risk Factors of Hernia in Patients With Rectus Abdominis Diastasis: A 10-Year Multicenter Retrospective Study.Frontiers in surgery · 2021Article
- Epidemiology of Barrett's Esophagus and Esophageal Adenocarcinoma: Implications for Screening and Surveillance.Gastrointestinal endoscopy clinics of North America · 2021Review
- Pyloroplasty and the risk of Barrett's esophagus in patients with gastroparesis.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2020Article
- Article
- Risk factors for Barrett's esophagus in young adults who underwent upper gastrointestinal endoscopy in a health examination center.Therapeutic advances in gastroenterology · 2019Article
- Barrett's Esophagus and Esophageal Adenocarcinoma: How Common Are They Really?Digestive diseases and sciences · 2018Review
- Contribution of Red Wine Consumption to Human Health Protection.Molecules (Basel, Switzerland) · 2018Review
- Presentation and Epidemiology of Gastroesophageal Reflux Disease.Gastroenterology · 2018Review
- Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett's esophagus.PloS one · 2018Article
- Dietary sugar/starches intake and Barrett's esophagus: a pooled analysis.European journal of epidemiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesResults from studies examining the association between alcohol consumption and the risk of Barrett's esophagus have been inconsistent. We assessed the risk of Barrett's esophagus associated with total and beverage-specific alcohol consumption by pooling individual participant data from five case-control studies participating in the international Barrett's and Esophageal Adenocarcinoma Consortium.
methodsFor analysis, there were 1,282 population-based controls, 1,418 controls with gastroesophageal reflux disease (GERD), and 1,169 patients with Barrett's esophagus (cases). We estimated study-specific odds ratios (ORs) and 95% confidence intervals (95% CI) using multivariable logistic regression models adjusted for age, sex, body mass index (BMI), education, smoking status, and GERD symptoms. Summary risk estimates were obtained by random-effects models. We also examined potential effect modification by sex, BMI, GERD symptoms, and cigarette smoking.
resultsFor comparisons with population-based controls, although there was a borderline statistically significant inverse association between any alcohol consumption and the risk of Barrett's esophagus (any vs. none, summary OR=0.77, 95% CI=0.60-1.00), risk did not decrease in a dose-response manner (Ptrend=0.72). Among alcohol types, wine was associated with a moderately reduced risk of Barrett's esophagus (any vs. none, OR=0.71, 95% CI=0.52-0.98); however, there was no consistent dose-response relationship (Ptrend=0.21). We found no association with alcohol consumption when cases were compared with GERD controls. Similar associations were observed across all strata of BMI, GERD symptoms, and cigarette smoking.
conclusionsConsistent with findings for esophageal adenocarcinoma, we found no evidence that alcohol consumption increases the risk of Barrett's esophagus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.