Evidence map›Paper›PMID 25047246›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2014

Bio-inspired cryo-ink preserves red blood cell phenotype and function during nanoliter vitrification.

Rami El Assal, Sinan Guven, Umut Atakan Gurkan, Irep Gozen, Hadi Shafiee, Sedef Dalbeyler, Noor Abdalla, Gawain Thomas, Wendy Fuld, Ben M W Illigens and 8 more

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Cryopreservation of NK and T Cells Without DMSO for Adoptive Cell-Based Immunotherapy.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2021
    Review
  8. Article
  9. [Experimental study on high throughput vitrification by micro-droplet spray method].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019
    Article
  10. Article
  11. Bioinspired Preservation of Natural Killer Cells for Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Article
  12. Bioinks for 3D bioprinting: an overview.Biomaterials science · 2018
    Review
  13. Bio-inspired solute enables preservation of human oocytes using minimum volume vitrification.Journal of tissue engineering and regenerative medicine · 2018
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Engineering cancer microenvironments forMaterials today (Kidlington, England) · 2015
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rami El AssalBio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, 94304, USA; Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division for Biomedical Engineering, Division of Infectious Diseases, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Sinan Guven
Umut Atakan Gurkan
Irep Gozen
Hadi Shafiee
Sedef Dalbeyler
Noor Abdalla
Gawain Thomas
Wendy Fuld
Ben M W Illigens
Jessica Estanislau
Joseph Khoory
Richard Kaufman
Claudia Zylberberg
Neal Lindeman
Qi Wen
Ionita Ghiran
Utkan Demirci

Funding

Rapid Fluorescence-Based Determination of Antibiotic SusceptibilityU54EB015408 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI PARRISH, JOHN A, SCHACHTER, STEVEN · 2012 to 2022
$49.2M
Modulation of erythrocyte function by complementR01HL096795 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GHIRAN, IONITA CALIN · 2011 to 2014
$1.7M
Minimizing the role of cryoprotectant toxicity for cryopreservationR01EB015776 · NIBIB · STANFORD UNIVERSITY · PI DEMIRCI, UTKAN · 2012 to 2015
$1.5M
Microfluidic Chip for Cryopreservation of Blood CellsR21HL095960 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMIRCI, UTKAN · 2011 to 2012
$491k
NHLBI NIH HHS R01 HL096795NHLBI NIH HHS R01-HL096795NHLBI NIH HHS R21 HL095960NHLBI NIH HHS R21-HL095960NIBIB NIH HHS R01 EB015776NIBIB NIH HHS R01-EB015776NIBIB NIH HHS U54EB15408
6 · The paper itself

Abstract

Current red-blood-cell cryopreservation methods utilize bulk volumes, causing cryo-injury of cells, which results in irreversible disruption of cell morphology, mechanics, and function. An innovative approach to preserve human red-blood-cell morphology, mechanics, and function following vitrification in nanoliter volumes is developed using a novel cryo-ink integrated with a bioprinting approach.

Indexed as

VitrificationAmino Acids, DiaminoBiomechanical PhenomenaBioprintingCryopreservationErythrocytesHumansInkIntracellular SpaceMicroscopy, Electron, ScanningMicroscopy, FluorescenceNanotechnologyNitric OxideReactive Oxygen SpeciesReceptors, Complement 3bAmino Acids, DiaminoCR1 protein, humanectoineNitric OxideReactive Oxygen SpeciesReceptors, Complement 3bbio-inspired materialsbio-printingcryoprotective agentsnanoliter vitrificationred blood cell cryopreservation

Identifiers

PMID25047246
PMCPMC4161503

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.