ArticlePloS one2014
Identification and characterisation of Aedes aegypti aldehyde dehydrogenases involved in pyrethroid metabolism.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Metabolomic Changes Underpinning Permethrin Resistance in theACS measurement science au · 2026Article
- Metabolomic changes underpinning permethrin resistance in thebioRxiv : the preprint server for biology · 2026Article
- Insecticide resistance status of Aedes aegypti and Aedes albopictus mosquitoes in southern Benin, West Africa.Tropical medicine and health · 2023Article
- A Genomic and Transcriptomic Study on the DDT-ResistantMicroorganisms · 2021Article
- From Global to Local-New Insights into Features of Pyrethroid Detoxification in Vector Mosquitoes.Insects · 2021Review
- Article
- Exome-wide association of deltamethrin resistance in Aedes aegypti from Mexico.Insect molecular biology · 2019Article
- Investigation of Relative Development and Reproductivity Fitness Cost in Three Insecticide-Resistant Strains ofInsects · 2019Article
- Biochemical Effects ofInsects · 2018Article
- Antimosquito property of Petroselinum crispum (Umbellifereae) against the pyrethroid resistant and susceptible strains of Aedes aegypti (Diptera: Culicidae).Environmental science and pollution research international · 2016Article
- Additive effect of knockdown resistance mutations, S989P, V1016G and F1534C, in a heterozygous genotype conferring pyrethroid resistance in Aedes aegypti in Thailand.Parasites & vectors · 2016Article
- Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors Aedes aegypti and Aedes albopictus from Malaysia.Parasites & vectors · 2015Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundPyrethroid insecticides, especially permethrin and deltamethrin, have been used extensively worldwide for mosquito control. However, insecticide resistance can spread through a population very rapidly under strong selection pressure from insecticide use. The upregulation of aldehyde dehydrogenase (ALDH) has been reported upon pyrethroid treatment. In Aedes aegypti, the increase in ALDH activity against the hydrolytic product of pyrethroid has been observed in DDT/permethrin-resistant strains. The objective of this study was to identify the role of individual ALDHs involved in pyrethroid metabolism. METHODOLOGY/PRINCIPAL
findingsThree ALDHs were identified; two of these, ALDH9948 and ALDH14080, were upregulated in terms of both mRNA and protein levels in a DDT/pyrethroid-resistant strain of Ae. aegypti. Recombinant ALDH9948 and ALDH14080 exhibited oxidase activities to catalyse the oxidation of a permethrin intermediate, phenoxybenzyl aldehyde (PBald), to phenoxybenzoic acid (PBacid). CONCLUSIONS/SIGNIFICANCE: ALDHs have been identified in association with permethrin resistance in Ae. aegypti. Characterisation of recombinant ALDHs confirmed the role of this protein in pyrethroid metabolism. Understanding the biochemical and molecular mechanisms of pyrethroid resistance provides information for improving vector control strategies.
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