ReviewOdontology2014
Roles of cathelicidins in inflammation and bone loss.
Review in Odontology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- 3D-printed vancomycin-eluting PGCL/MXene bifunctional scaffold for management of infected bone defects.Materials today. Bio · 2025Article
- Bacteriostatic and Immunomodulatory Effect of Xylocaine in the Context ofACS bio & med chem Au · 2025Article
- Local Defense Factors in Cleft-Affected Palate in Children before and during Milk Dentition Age: A Pilot Study.Journal of personalized medicine · 2023Article
- Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration.Materials today. Bio · 2022Review
- Cathelicidin LL-37 improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the Wnt/beta-catenin pathway.Physiological research · 2022Article
- Cathelicidin LL-37 in Health and Diseases of the Oral Cavity.Biomedicines · 2022Review
- Overview of signal transduction between LL37 and bone marrow-derived MSCs.Journal of molecular histology · 2022Review
- Comparative antler proteome of sika deer from different developmental stages.Scientific reports · 2021Article
- Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute.Regenerative biomaterials · 2021Article
- Activity of five antimicrobial peptides against periodontal as well as non-periodontal pathogenic strains.Journal of oral microbiology · 2020Article
- The Critical Role of Tryptophan in the Antimicrobial Activity and Cell Toxicity of the Duck Antimicrobial Peptide DCATH.Frontiers in microbiology · 2020Article
- Significance of LL-37 on Immunomodulation and Disease Outcome.BioMed research international · 2020Review
- Cathelicidins and the Onset of Labour.Scientific reports · 2019Article
- Sensitivity of caries pathogens to antimicrobial peptides related to caries risk.Clinical oral investigations · 2018Article
- OmpA-Like Proteins ofJournal of pathogens · 2018Article
- Effects of Virus-associated Molecular Patterns on the Expression of Cathelicidins in the Hen Vagina.The journal of poultry science · 2016Article
- Immune and regulatory functions of neutrophils in inflammatory bone loss.Seminars in immunology · 2016Review
- Identification of a novel cathelicidin antimicrobial peptide from ducks and determination of its functional activity and antibacterial mechanism.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Body surface tissues, such as the oral cavity, contact directly with the external environment and are continuously exposed to microbial insults. Cathelicidins are a family of antimicrobial peptides that are found in mammalian species. Humans and mice have only one cathelicidin. Cathelicidins are expressed in a variety of surface tissues. In addition, they are abundantly expressed in bone and bone marrow. Infectious stimuli upregulate the expression of cathelicidins, which play sentinel roles in allowing the tissues to fight against microbial challenges. Cathelicidins disrupt membranes of microorganisms and kill them. They also neutralize microbe-derived pathogens, such as lipopolysaccharide (LPS) and flagellin. Besides their antimicrobial functions, cathelicidins can also control actions of host cells, such as chemotaxis, proliferation, and cytokine production, through binding to the receptors expressed on them. LPS and flagellin induce osteoclastogenesis and the production of cathelicidins, which can in turn inhibit osteoclastogenesis. Thus, cathelicidins contribute to maintaining microbiota-host homeostasis and promoting repair responses to inflammatory insults. In this review, we describe recent findings on the multiple roles of cathelicidins in host defense. We also discuss the significance of the human cathelicidin, LL-37, as a pharmaceutical target for the treatment of inflammation and bone loss in infectious diseases, such as periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.