Evidence map›Paper›PMID 25047058›Full record

ReviewConnective tissue research2015

Extracellular matrix regulation in the muscle satellite cell niche.

Kelsey Thomas, Adam J Engler, Gretchen A Meyer

Abstract readReview
In one paragraph

Review in Connective tissue research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed.

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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kelsey ThomasDepartment of Biomedical Sciences and.
Adam J Engler
Gretchen A Meyer

Funding

"Smart" Materials to Engineer a More Complete Stem Cell NicheDP2OD006460 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J · 2009 to 2009
$2.3M
Promoting regeneration in muscular dystrophy with adipose derived stem cells.F32AR063588 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEYER, GRETCHEN A · 2012 to 2013
$96k
NIAMS NIH HHS F32 AR063588NIH HHS DP2 OD006460
6 · The paper itself

Abstract

Increasing evidence points to extracellular matrix (ECM) components playing integral roles in regulating the muscle satellite cell (SC) niche. Even small alterations to the niche ECM can have profound effects on SC localization, activation, self-renewal, proliferation and differentiation. This review will focus on the ECM components that comprise the niche, how they are modulated in health and disease and how these changes are thought to affect SC function. Particular emphasis will be placed on the pathological niche and interventions that aim to restore healthy structure and function, as a better understanding of the interplay between the SC and its environment will drive more targeted and effective therapies.

Indexed as

Stem Cell NicheAnimalsCell DifferentiationExtracellular MatrixHumansModels, BiologicalSatellite Cells, Skeletal MuscleStem Cell TransplantationBasement membranecollagenproteoglycansatellite cellstem cell

Identifiers

PMID25047058
PMCPMC4464813

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.