ArticleOsteoarthritis and cartilage2014
Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth.
Article in Osteoarthritis and cartilage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Review
- Functional changes to Achilles tendon and enthesis in an adolescent mouse model of testosterone hormone therapy.Connective tissue research · 2025Article
- Tissue stiffness heterogeneity in the jaw and temporomandibular joint: its impact on tumor metabolism and considerations forFrontiers in physiology · 2025Review
- The Temporomandibular Joint and the Human Body: A New Perspective on Cross Talk.Dentistry journal · 2024Review
- Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3β/β-CATENIN pathway.Journal of translational medicine · 2024Article
- Functional Changes to Achilles Tendon and Enthesis in a Mouse Model of an Adolescent Masculine Gender-Affirming Hormone Treatment.bioRxiv : the preprint server for biology · 2024Article
- Sex-dependent variation in cartilage adaptation: from degeneration to regeneration.Biology of sex differences · 2023Review
- SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Incidental findings of temporomandibular joint osteoarthritis and its variability based on age and sex.Imaging science in dentistry · 2020Article
- Estrogen signaling impacts temporomandibular joint and periodontal disease pathology.Odontology · 2020Review
- Emerging Potential of Exosomes in Regenerative Medicine for Temporomandibular Joint Osteoarthritis.International journal of molecular sciences · 2020Review
- Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism.International journal of molecular sciences · 2019Article
- Estrogen-Related Receptor γ Induces Angiogenesis and Extracellular Matrix Degradation of Temporomandibular Joint Osteoarthritis in Rats.Frontiers in pharmacology · 2019Article
- Structure-Function Relationships of the Temporomandibular Joint in Response to Altered Loading.Journal of oral & facial pain and headache · 2019Article
- Temporomandibular Joint Disorders in Older Adults.Journal of the American Geriatrics Society · 2018Review
- Estrogen Promotes Mandibular Condylar Fibrocartilage Chondrogenesis and Inhibits Degeneration via Estrogen Receptor Alpha in Female Mice.Scientific reports · 2018Article
- Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy.PloS one · 2018Article
- Estrogen receptor alpha mediates mandibular condylar cartilage growth in male mice.Orthodontics & craniofacial research · 2017Article
- Sex differences in the estrogen-dependent regulation of temporomandibular joint remodeling in altered loading.Osteoarthritis and cartilage · 2017Article
- Estradiol via estrogen receptor beta inhibits chondrogenesis of mouse vertebral growth plate in vitro.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTemporomandibular joint (TMJ) diseases predominantly afflict women, suggesting a role for female hormones in the disease process. However, little is known about the role of estrogen receptor (ER) signaling in regulating mandibular condylar cartilage growth. Therefore, the goal of this study was to examine the effects of altered estrogen levels on the mandibular condylar cartilage in wild type (WT) and ER beta Knockout (KO) mice. MATERIALS AND
methods21-day-old female WT (n = 37) and ER beta KO mice (n = 36) were either sham operated or ovariectomized, and treated with either placebo or estradiol. The mandibular condylar cartilage was evaluated by histomorphometry, proliferation was analyzed by double ethynyl-2'-deoxyuridine/bromodeoxyuridine (EdU/BrdU) labeling, and assays on gene and protein expression of chondrocyte maturation markers were performed.
resultsIn WT mice, ovariectomy caused a significant increase in mandibular condylar cartilage cell numbers, a significant increase in Sox9 expression and a significant increase in proliferation compared with sham operated WT mice. In contrast, ovariectomy did not cause any of these effects in the ER beta KO mice. Estrogen replacement treatment in ovariectomized WT mice caused a significant decrease in ER alpha expression and a significant increase in Sost expression compared with ovariectomized mice treated with placebo. Estrogen replacement treatment in ovariectomized ER beta KO mice caused a significant increase in Col2 expression, no change in ER alpha expression, and a significant increase in Sost expression.
conclusionEstrogen via ER beta inhibits proliferation and ER alpha expression while estrogen independent of ER beta induces Col2 and Sost expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.