ArticleJournal of investigative medicine : the official publication of the American Federation for Clinical Research2014
Destruction of white matter integrity in patients with mild cognitive impairment and Alzheimer disease.
Article in Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- White matter alterations in mild cognitive impairment revealed by meta-analysis of diffusion tensor imaging using tract-based spatial statistics.Brain imaging and behavior · 2023Pooled it
- Association between neuroticism and brain-wide structural outcomes: Mediation by vascular and mental conditions.Psychological medicine · 2025Article
- Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA.Scientific reports · 2023Article
- Cholinergic white matter pathways along the Alzheimer's disease continuum.Brain : a journal of neurology · 2023Article
- Structural and functional differences in the brains of patients with MCI with and without depressive symptoms and their relations with Alzheimer's disease: an MRI study.Psychoradiology · 2023Article
- Tau-mediated axonal degeneration is prevented by activation of the WldBrain communications · 2023Article
- Free-water diffusion tensor imaging improves the accuracy and sensitivity of white matter analysis in Alzheimer's disease.Scientific reports · 2021Article
- White Matter Microstructure is Associated with Serum Clusterin and Everyday Functioning in a Sample of Nondemented Older Adults.Current Alzheimer research · 2021Article
- Cerebral white matter diffusion properties and free-water with obstructive sleep apnea severity in older adults.Human brain mapping · 2020Article
- Systems modeling of white matter microstructural abnormalities in Alzheimer's disease.NeuroImage. Clinical · 2020Article
- The cumulative effect of small vessel disease lesions is reflected in structural brain networks of memory clinic patients.NeuroImage. Clinical · 2018Article
- Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Review
- Widespread white matter and conduction defects in PSEN1-related spastic paraparesis.Neurobiology of aging · 2016Article
- Tract-based analysis of white matter degeneration in Alzheimer's disease.Neuroscience · 2015Article
- Article
- Longitudinal impact of cholinesterase inhibitors on cholinergic white matter integrity in mild cognitive impairment: A diffusion MRI study.Journal of Alzheimer's disease reportsArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundAccumulating evidence shows that gradual loss of white matter integrity plays an important role in the development of Alzheimer disease (AD).
objectiveThe aim of this research was to study the microstructural integrity of white matter in AD in vivo.
methodsGlobal fractional anisotropy, global axial diffusivity (AxD), and global radial diffusivity (RD) were analyzed in subjects with normal controls (NC), mild cognitive impairment (MCI), and AD using Alzheimer's Disease Neuroimaging Initiative data (total N = 210). We further compared specific white matter tracts among the 3 groups.
resultsCompared with the NC group, the MCI group had significantly increased global AxD and global RD. Compared with the NC and MCI groups, the AD group had significantly decreased global fractional anisotropy, increased global AxD, and increased global RD. With regard to specific white matter tracts, in the MCI group, we found increased AxD and increased RD in the external capsule, part of the lateral cholinergic pathway, in addition to the tracts connecting the limbic regions, predominantly in the left hemisphere. In the AD group, white matter abnormalities were widespread, including in the external capsule (cholinergic pathway) and limbic region tracts as well as tracts connecting anterior to posterior regions bilaterally.
conclusionsThe radiographic manifestation of damaged white matter microstructural integrity in the cholinergic pathway in MCI patients may provide a rational basis for the use of cholinesterase inhibitor drugs in the MCI stage of AD.
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