ArticleBioMed research international2014
The impact of coinfections and their simultaneous transmission on antigenic diversity and epidemic cycling of infectious diseases.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Modelling assessment of epidemiological strategies based on self-screening tools.Communications medicine · 2026Article
- Modelling behavioural changes and vaccination in the transmission of respiratory viruses with co-infection.Journal of mathematical biology · 2025Article
- Opportunist Coinfections by Nontuberculous Mycobacteria and Fungi in Immunocompromised Patients.Antibiotics (Basel, Switzerland) · 2020Review
- Association of Schistosoma haematobium infection morbidity and severity on co-infections in pre-school age children living in a rural endemic area in Zimbabwe.BMC public health · 2020Article
- Positively interacting strains that co-circulate within a network structured population induce cycling epidemics of Mycoplasma pneumoniae.Scientific reports · 2019Article
- Coinfection Dynamics of Two Diseases in a Single Host Population.Journal of mathematical analysis and applications · 2016Article
- Epidemic cycling in a multi-strain SIRS epidemic network model.Theoretical biology & medical modelling · 2016Article
- Construction of the influenza A virus transmission tree in a college-based population: co-transmission and interactions between influenza A viruses.BMC infectious diseases · 2016Article
- Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemic cycling in human infectious diseases is common; however, its underlying mechanisms have been poorly understood. Much effort has been made to search for external mechanisms. Multiple strains of an infectious agent were usually observed and coinfections were frequent; further, empirical evidence indicates the simultaneous transmission of coinfections. To explore intrinsic mechanisms for epidemic cycling, in this study we consider a multistrain Susceptible-Infected-Recovered-Susceptible epidemic model by including coinfections and simultaneous transmission. We show that coinfections and their simultaneous transmission widen the parameter range for coexistence and coinfections become popular when strains enhance each other and the immunity wanes quickly. However, the total prevalence is nearly independent of these characteristics and approximated by that of one-strain model. With sufficient simultaneous transmission and antigenic diversity, cyclical epidemics can be generated even when strains interfere with each other by reducing infectivity. This indicates that strain interactions within coinfections and cross-immunity during subsequent infection provide a possible intrinsic mechanism for epidemic cycling.
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Registered trials
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