ArticleCurrent behavioral neuroscience reports2014
The Genetics, Neurogenetics and Pharmacogenetics of Addiction.
Article in Current behavioral neuroscience reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Etiology of longitudinal associations between subjective effects and substance use disorders in a clinical sample.Addictive behaviors reports · 2026Article
- Reduced MOV10 reveals novel functional cortical connections in an increased fear response.bioRxiv : the preprint server for biology · 2026Article
- "I'm a Survivor": Perceptions of Chronic Disease and Survivorship Among Individuals in Long-Term Remission from Opioid Use Disorder.Journal of general internal medicine · 2022Article
- Application of Research Domain Criteria to childhood and adolescent impulsive and addictive disorders: Implications for treatment.Clinical psychology review · 2018Review
- Melatonin in drug addiction and addiction management: Exploring an evolving multidimensional relationship.World journal of psychiatry · 2018Review
- Environmental, genetic and epigenetic contributions to cocaine addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
- Tulsa 1000: a naturalistic study protocol for multilevel assessment and outcome prediction in a large psychiatric sample.BMJ open · 2018Observational
- A GABRA2 polymorphism improves a model for prediction of drinking initiation.Alcohol (Fayetteville, N.Y.) · 2017Article
- Alcohol effects on the epigenome in the germline: Role in the inheritance of alcohol-related pathology.Alcohol (Fayetteville, N.Y.) · 2017Review
- Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans.Genetics · 2016Article
- Single nucleotide polymorphism near CREB1, rs7591784, is associated with pretreatment methamphetamine use frequency and outcome of outpatient treatment for methamphetamine use disorder.Journal of psychiatric research · 2016Article
- Neurobiologic Advances from the Brain Disease Model of Addiction.The New England journal of medicine · 2016Review
- Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction.Frontiers in neuroscience · 2016Review
- Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine.Progress in biophysics and molecular biology · 2015Review
- Individual Consistency of Feather Pecking Behavior in Laying Hens: Once a Feather Pecker Always a Feather Pecker?Frontiers in veterinary science · 2015Article
- Behavioral Genetics in Criminal and Civil Courts.Harvard review of psychiatryReview
- Often Overlooked and Ignored, but Do Not Underestimate Its Relevance: ADHD in Addiction - Addiction in ADHD.European addiction researchArticle
- The Molecular Neurobiology of Twelve Steps Program & Fellowship: Connecting the Dots for Recovery.Journal of reward deficiency syndromeArticle
- NIDA-Drug Addiction Treatment Outcome Study (DATOS) Relapse as a Function of Spirituality/Religiosity.Journal of reward deficiency syndromeArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Addictions are prevalent psychiatric disorders that confer remarkable personal and social burden. Despite substantial evidence for their moderate, yet robust, heritability (approx. 50%), specific genetic mechanisms underlying their development and maintenance remain unclear. The goal of this selective review is to highlight progress in unveiling the genetic underpinnings of addiction. First, we revisit the basis for heritable variation in addiction before reviewing the most replicable candidate gene findings and emerging signals from genomewide association studies for alcohol, nicotine and cannabis addictions. Second, we survey the modest but growing field of neurogenetics examining how genetic variation influences corticostriatal structure, function, and connectivity to identify neural mechanisms that may underlie associations between genetic variation and addiction. Third, we outline how extant genomic findings are being used to develop and refine pharmacotherapies. Finally, as sample sizes for genetically informed studies of addiction approach critical mass, we posit five exciting possibilities that may propel further discovery (improved phenotyping, rare variant discovery, gene-environment interplay, epigenetics, and novel neuroimaging designs).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.