ArticleCase reports in pathology2014
An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor.
Article in Case reports in pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Laparoscopic Hepatectomy for Hepatic Inflammatory Myofibroblastic Tumor: A Case Report.Surgical case reports · 2026Article
- Inflammatory Myofibroblastic Tumour of the Bladder in a Young Male: A Rare Case Report.Cureus · 2025Article
- Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment.Oncology research · 2024Review
- Recurrent Inflammatory Myofibroblastic Tumor of Larynx Harboring a Novel THBS1::ALK Fusion.International journal of genomics · 2024Review
- Inflammatory myofibroblastic tumor of the lung involving the central nervous system in pediatric patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Article
- Inflammatory Myofibroblastic Tumor of the Hilar Bile Duct: A Case Report and Literature Review.Frontiers in surgery · 2022Article
- Inflammatory myofibroblastic tumor in the pancreatic neck: a rare case report and literature review.Gland surgery · 2021Article
- Molecular Tumor Board Guides Successful Treatment of a Rare, Locally Aggressive, Uterine Mesenchymal Neoplasm.JCO precision oncology · 2021Article
- Pancreatic inflammatory myofibroblastic tumor presenting with extracolonic obstruction.Turkish journal of surgery · 2020Article
- Effectiveness of Crizotinib for Inflammatory Myofibroblastic Tumor with ALK mutation.Internal medicine (Tokyo, Japan) · 2019Article
- First-Line Therapy for Metastatic Soft Tissue Sarcoma.Current treatment options in oncology · 2019Review
- Transtracheal endoscopic-assisted resection of a rare inflammatory myofibroblastic tumour in adult trachea: a case report.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2018Article
- Inflammatory Myofibroblastic Tumors in Paranasal Sinus and Nasopharynx: A Clinical Retrospective Study of 13 Cases.BioMed research international · 2018Article
- Inflammatory myofibroblastic tumor of the lumbar spinal canal: A Case Report With Literature Review.Medicine · 2017Review
- Sinonasal Inflammatory Myofibroblastic Tumor with Anaplastic Lymphoma Kinase 1 Rearrangement: Case Study and Literature Review.Head and neck pathology · 2017Review
- Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center.Journal of pathology and translational medicine · 2017Article
- Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: a case report.Diagnostic pathology · 2016Article
- Endobronchial Inflammatory Myofibroblastic Tumour-A Case Report.Journal of clinical and diagnostic research : JCDR · 2016Article
- Remission of ALK-negative primary pulmonary inflammatory myofibroblastic tumor on treatment with clarithromycin: A case report and review of the literature.Oncology letters · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic inflammatory myofibroblastic tumor is an exceedingly rare entity. A 45-year-old Hispanic female presented with a 6-month history of left-sided thigh pain, low back pain, and generalized weakness. PET/CT scan revealed abnormal activity in the liver, adrenal gland, and pancreas. MRI of the abdomen demonstrated two 6-7 cm masses in the liver. MRI of the lumbar spine demonstrated lesions in the L2 to L4 spinous processes, paraspinal muscles, and subcutaneous tissues, as well as an 8 mm enhancing intradural lesion at T11, all thought to be metastatic disease. A biopsy of the liver showed portal tract expansion by a spindle cell proliferation rich in inflammation. Tumor cells showed immunoreactivity for smooth muscle actin and anaplastic lymphoma kinase 1 (ALK1). Tissue from the L5 vertebra showed a process histologically identical to that seen in the liver. FISH analysis of these lesions demonstrated an ALK (2p23) gene rearrangement. The patient was successfully treated with an ALK-inhibitor, Crizotinib, and is now in complete remission. We present the first reported case, to our knowledge, of inflammatory myofibroblastic tumor with systemic manifestations and ALK translocation. This case is a prime example of how personalized medicine has vastly improved patient care through the use of molecular-targeted therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.