ArticleBMC clinical pathology2014
Comparability of HbA1c and lipids measured with dried blood spot versus venous samples: a systematic review and meta-analysis.
Article in BMC clinical pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Dried Blood Spots to Assess Cardiovascular-Kidney-Metabolic Health.Journal of the American Heart Association · 2025Pooled it
- Counseling and Cardiovascular Disease Risk Factor Control in Long-Term Cancer Survivors: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Method Comparison of Dried Blood Spot and Plasma Apolipoprotein B Measurement on a Semi-Automated Analyser: Toward Accessible Lipid Profiling in Resource-Limited Settings.Analytical science advances · 2026Article
- Innovative approaches to early detection of cardiovascular disease and diabetes risk: focus on glucose and cholesterol measuring.European journal of public health · 2026Article
- Strategies to Overcome Hematocrit and Volume Bias in Dried Blood Spot Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Effect of theBMJ open · 2025Article
- Prevalence, awareness, treatment, and control of diabetes in India: a nationally representative survey of adults aged 45 years and older.The Lancet. Global health · 2025Article
- DiaBetter Together: Clinical trial protocol for a strengths-based Peer Mentor intervention for young adults with type 1 diabetes transitioning to adult care.Contemporary clinical trials · 2024Article
- Association of birth weight with risk of diabetes mellitus in adolescence and early adulthood: analysis of the Indonesian Family Life Survey.Annals of pediatric endocrinology & metabolism · 2023Article
- Adolescent Psychological Assets and Cardiometabolic Health Maintenance in Adulthood: Implications for Health Equity.Journal of the American Heart Association · 2023Article
- Protocol for the Promoting Resilience in Stress Management (PRISM) intervention: A multi-site randomized controlled trial for adolescents with type 1 diabetes.Contemporary clinical trials · 2023Article
- Postal methods for monitoring HbA1c in diabetes mellitus: a protocol for systematic review.BJGP open · 2022Article
- Validation and feasibility of a postal system for remote monitoring of HbA1c.BMJ open diabetes research & care · 2021Article
- HbADiabetic medicine : a journal of the British Diabetic Association · 2020Article
- Extraction of Lipids from Liquid Biological Samples for High-Throughput Lipidomics.Molecules (Basel, Switzerland) · 2020Article
- Diabetes and Cardiovascular Disease Risk in Cambodian Refugees.Journal of immigrant and minority health · 2016Article
- Collection and laboratory methods for dried blood spots for hemoglobin A1c and total and high-density lipoprotein cholesterol in population-based surveys.Clinica chimica acta; international journal of clinical chemistry · 2015Article
- The use of dried blood spot sampling for the measurement of HbA1c: a cross-sectional study.BMC clinical pathology · 2015Article
- HPLC-based Measurement of Glycated Hemoglobin using Dried Blood Spots Collected under Adverse Field Conditions.Biodemography and social biologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLevels of haemoglobin A1c (HbA1c) and blood lipids are important determinants of risk in patients with diabetes. Standard analysis methods based upon venous blood samples can be logistically challenging in resource-poor settings where much of the diabetes epidemic is occurring. Dried blood spots (DBS) provide a simple alternative method for sample collection but the comparability of data from analyses based on DBS is not well established.
methodsWe conducted a systematic review and meta-analysis to define the association of findings for HbA1c and blood lipids for analyses based upon standard methods compared to DBS. The Cochrane, Embase and Medline databases were searched for relevant reports and summary regression lines were estimated.
results705 abstracts were found by the initial electronic search with 6 further reports identified by manual review of the full papers. 16 studies provided data for one or more outcomes of interest. There was a close agreement between the results for HbA1c assays based on venous and DBS samples (DBS = 0.9858venous + 0.3809), except for assays based upon affinity chromatography. Significant adjustment was required for assays of total cholesterol (DBS = 0.6807venous + 1.151) but results for triglycerides (DBS = 0.9557venous + 0.1427) were directly comparable.
conclusionsFor HbA1c and selected blood lipids, assays based on DBS samples are clearly associated with assays based on standard venous samples. There are, however, significant uncertainties about the nature of these associations and there is a need for standardisation of the sample collection, transportation, storage and analysis methods before the technique can be considered mainstream. This should be a research priority because better elucidation of metabolic risks in resource poor settings, where venous sampling is infeasible, will be key to addressing the global epidemic of cardiovascular diseases.
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