ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2014
Role of semaphorin-1a in the developing visual system of the disease vector mosquito Aedes aegypti.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Challenges of Robust RNAi-Mediated Gene Silencing inInternational journal of molecular sciences · 2024Article
- Opsin1 regulates light-evoked avoidance behavior in Aedes albopictus.BMC biology · 2022Article
- Advances in oral RNAi for disease vector mosquito research and control.Current opinion in insect science · 2020Review
- Delivery Methods for RNAi in Mosquito Larvae.Journal of insect science (Online) · 2020Review
- Characterization of plexinA and two distinct semaphorin1a transcripts in the developing and adult cricket Gryllus bimaculatus.The Journal of comparative neurology · 2020Article
- Semaphorin-1a-like gene plays an important role in the embryonic development of silkworm, Bombyx mori.PloS one · 2020Article
- Characterization of a broad-based mosquito yeast interfering RNA larvicide with a conserved target site in mosquito semaphorin-1a genes.Parasites & vectors · 2019Article
- Saccharomyces cerevisiae (Baker's Yeast) as an Interfering RNA Expression and Delivery System.Current drug targets · 2019Review
- Preparation and Use of a Yeast shRNA Delivery System for Gene Silencing in Mosquito Larvae.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Yeast interfering RNA larvicides targeting neural genes induce high rates of Anopheles larval mortality.Malaria journal · 2017Article
- Lure-and-Kill Yeast Interfering RNA Larvicides Targeting Neural Genes in the Human Disease Vector Mosquito Aedes aegypti.Scientific reports · 2017Article
- Expression and light-triggered movement of rhodopsins in the larval visual system of mosquitoes.The Journal of experimental biology · 2015Article
- Developmental neurogenetics of sexual dimorphism inFrontiers in ecology and evolutionArticle
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Authors and funding
9 authors.
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Abstract
backgroundDespite the devastating impact of mosquito-borne illnesses on human health, very little is known about mosquito developmental biology, including development of the mosquito visual system. Mosquitoes possess functional adult compound eyes as larvae, a trait that makes them an interesting model in which to study comparative developmental genetics. Here, we functionally characterize visual system development in the dengue and yellow fever vector mosquito Aedes aegypti, in which we use chitosan/siRNA nanoparticles to target the axon guidance gene semaphorin-1a (sema1a).
resultsImmunohistochemical analyses revealed the progression of visual sensory neuron targeting that results in generation of the retinotopic map in the mosquito optic lobe. Loss of sema1a function led to optic lobe phenotypes, including defective targeting of visual sensory neurons and failed formation of the retinotopic map. These sema1a knockdown phenotypes correlated with behavioral defects in larval photoavoidance.
conclusionsThe results of this investigation indicate that Sema1a is required for optic lobe development in A. aegypti and highlight the behavioral importance of a functioning visual system in preadult mosquitoes.
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