ReviewIUBMB life2014
Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.
Review in IUBMB life, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
136 citing papers in PubMed, 270 citations in OpenAlex.
- Synergistic Ionic Liquid-Antibiotic Combination as a Strategy against Methicillin-ResistantACS omega · 2026Article
- Mislocalization of PBPs inMicrobiology spectrum · 2026Article
- Development and comparative evaluation of in vitro, ex vivo, and in vivo models for the assessment of broad-spectrum topical antimicrobial efficacy.Scientific reports · 2026Article
- Unique Mānuka Factor (UMF)-dependent antimicrobial activity of Mānuka honey against respiratory pathogens cannot be explained by sugar and methylglyoxal alone.Microbiology (Reading, England) · 2026Article
- Current Recommendations, Antibiotic Resistance, and Emerging Treatments for Gram-Positive Ocular Infections in the United States.Antibiotics (Basel, Switzerland) · 2026Review
- Article
- Current State of the Fight Against Antimicrobial Resistance: What Are the Different Strategies for Tomorrow?Antibiotics (Basel, Switzerland) · 2026Review
- Natural Products and Antimicrobial Nanoparticles Against Methicillin-ResistantPharmaceutics · 2026Review
- Penicillin-Binding Protein-4 (PBP4) ofMicroorganisms · 2026Review
- Article
- Methicillin-resistantAntimicrobial agents and chemotherapy · 2026Article
- Synergistic Immunoenhancement of Recombinant PBP2a Vaccine Candidate by Biogenic Selenium Nanoparticles and MF59 Against Methicillin-Resistant Staphylococcus Aureus.Current microbiology · 2026Article
- Eco-Friendly Synthesis of Magnesium Oxide Nanoparticles Using Citrullus colocynthis and their Synergistic Antimicrobial Activity against Drug-Resistant Pathogens.Current microbiology · 2026Article
- Fluorescence spectroscopy as a tool for differentiating methicillin resistance in clinical isolates of Staphylococcus aureus.Journal of fluorescence · 2026Article
- Marine Bacteria as a Source of Antibiotics AgainstMarine drugs · 2026Review
- Staphylococcus aureus periprosthetic joint infection and its pathogenesis in total hip and knee arthroplasty: a narrative review.EFORT open reviews · 2026Review
- Occurrence, molecular confirmation, and multidrug resistance of methicillin-resistantVeterinary world · 2026Article
- CRISPR-driven strategies to disrupt methicillin-resistantFrontiers in cellular and infection microbiology · 2026Review
- Network analysis of antimicrobial resistance inNAR genomics and bioinformatics · 2025Article
- Clinical and laboratory indicators predicting coagulase-negative staphylococci as a cause of bloodstream infection among children below five years of age admitted at a tertiary hospital in Dar es Salaam, Tanzania.Annals of medicine · 2025Article
76 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of the challenge by β-lactam antibiotics. The activity of this protein is regulated by allostery at a site 60 Å distant from the active site, where crosslinking of cell wall takes place. This review discusses the state of knowledge on this important enzyme of cell-wall biosynthesis in MRSA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.