ArticleHuman brain mapping2014
Evoked effective connectivity of the human neocortex.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Trends and hotspots of stereoelectroencephalogram from 2002 to 2023: a bibliometric analysis.Frontiers in neurology · 2024Pooled it
- On the impact of tactile processing on motor cortex: how touch shapes motor behaviour.Brain structure & function · 2026Review
- A Systematic Characterization of Causal Interactions Between Human Visual Areas.bioRxiv : the preprint server for biology · 2026Article
- Multimodal evidence for hippocampal engagement and modulation by functional connectivity-guided parietal TMS.Nature communications · 2026Article
- Directed cortico-limbic dialogue in the human brain.Nature communications · 2026Article
- ER-detect: A pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data.Journal of neuroscience methods · 2025Article
- Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mapping the Epileptogenic Brain Using Low-Frequency Stimulation: Two Decades of Advances and Uncertainties.Journal of clinical medicine · 2025Review
- Theta-burst direct electrical stimulation remodels human brain networks.Nature communications · 2024Article
- Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans.Scientific reports · 2024Article
- ER-detect: a pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data.bioRxiv : the preprint server for biology · 2024Article
- Analyzing asymmetry in brain hierarchies with a linear state-space model of resting-state fMRI data.Network neuroscience (Cambridge, Mass.) · 2024Article
- Effective connectivity relates seizure outcome to electrode placement in responsive neurostimulation.Brain communications · 2024Article
- Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex.Nature communications · 2023Article
- Advances in Deep Brain Stimulation: From Mechanisms to Applications.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Time-frequency signatures evoked by single-pulse deep brain stimulation to the subcallosal cingulate.Frontiers in human neuroscience · 2022Article
- Inducing neuroplasticity through intracranial θ-burst stimulation in the human sensorimotor cortex.Journal of neurophysiology · 2021Article
- Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity.NeuroImage · 2021Article
- Novel Asleep Techniques for Intraoperative Assessment of Brain Connectivity.Frontiers in neurology · 2021Article
- Dynamic tractography: Integrating cortico-cortical evoked potentials and diffusion imaging.NeuroImage · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The role of cortical connectivity in brain function and pathology is increasingly being recognized. While in vivo magnetic resonance imaging studies have provided important insights into anatomical and functional connectivity, these methodologies are limited in their ability to detect electrophysiological activity and the causal relationships that underlie effective connectivity. Here, we describe results of cortico-cortical evoked potential (CCEP) mapping using single pulse electrical stimulation in 25 patients undergoing seizure monitoring with subdural electrode arrays. Mapping was performed by stimulating adjacent electrode pairs and recording CCEPs from the remainder of the electrode array. CCEPs reliably revealed functional networks and showed an inverse relationship to distance between sites. Coregistration to Brodmann areas (BA) permitted group analysis. Connections were frequently directional with 43% of early responses and 50% of late responses of connections reflecting relative dominance of incoming or outgoing connections. The most consistent connections were seen as outgoing from motor cortex, BA6-BA9, somatosensory (SS) cortex, anterior cingulate cortex, and Broca's area. Network topology revealed motor, SS, and premotor cortices along with BA9 and BA10 and language areas to serve as hubs for cortical connections. BA20 and BA39 demonstrated the most consistent dominance of outdegree connections, while BA5, BA7, auditory cortex, and anterior cingulum demonstrated relatively greater indegree. This multicenter, large-scale, directional study of local and long-range cortical connectivity using direct recordings from awake, humans will aid the interpretation of noninvasive functional connectome studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.