ArticleAngewandte Chemie (International ed. in English)2014
Integration of platinum nanoparticles with a volumetric bar-chart chip for biomarker assays.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Development of an immunoassay lollipop using syringe-autoinjected visual distance readout for point-of-care testing.Analytical and bioanalytical chemistry · 2025Article
- Overview of Gas-Generating-Reaction-Based Immunoassays.Biosensors · 2024Review
- Catalase Detection via Membrane-Based Pressure Sensors.Molecules (Basel, Switzerland) · 2024Article
- Magnetic iron oxide-based nanozymes: from synthesis to application.Nanoscale advances · 2024Review
- Microfluidic platforms integrated with nano-sensors for point-of-care bioanalysis.Trends in analytical chemistry : TRAC · 2022Article
- DNAzyme-controlled plasmonic coupling for SERS-based determination of Salmonella typhimurium using hybridization chain reaction self-assembled G-quadruplex.Mikrochimica acta · 2022Article
- Nanomaterial-assisted microfluidics for multiplex assays.Mikrochimica acta · 2022Review
- Remotely tunable microfluidic platform driven by nanomaterial-mediated on-demand photothermal pumping.Lab on a chip · 2020Article
- Rational Design and Biological Application of Antioxidant Nanozymes.Frontiers in chemistry · 2020Review
- Quantitation of Femtomolar-Level Protein Biomarkers Using a Simple Microbubbling Digital Assay and Bright-Field Smartphone Imaging.Angewandte Chemie (International ed. in English) · 2019Review
- Microfluidic device for the analysis of MDR cancerous cell-derived exosomes' response to nanotherapy.Biomedical microdevices · 2019Article
- Fast, Sensitive, and Quantitative Point-of-Care Platform for the Assessment of Drugs of Abuse in Urine, Serum, and Whole Blood.Analytical chemistry · 2017Article
- A Nanostructured Microfluidic Immunoassay Platform for Highly Sensitive Infectious Pathogen Detection.Small (Weinheim an der Bergstrasse, Germany) · 2017Article
- Synergistic Degradation of a Hyperuricemia-Causing Metabolite Using One-Pot Enzyme-Nanozyme Cascade Reactions.Scientific reports · 2017Article
- Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetic for Biomedical Applications.Theranostics · 2017Review
- Integrative volumetric bar-chart chip for rapid and quantitative point-of-care detection of myocardial infarction biomarkers.Lab on a chip · 2016Article
- Recent Progress of Microfluidics in Translational Applications.Advanced healthcare materials · 2016Review
- Nanoporous Glass Integrated in Volumetric Bar-Chart Chip for Point-of-Care Diagnostics of Non-Small Cell Lung Cancer.ACS nano · 2016Article
- Cobalt-Porphyrin-Platinum-Functionalized Reduced Graphene Oxide Hybrid Nanostructures: A Novel Peroxidase Mimetic System For Improved Electrochemical Immunoassay.Scientific reports · 2015Article
- A microfluidic platform with digital readout and ultra-low detection limit for quantitative point-of-care diagnostics.Lab on a chip · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Platinum nanoparticles (PtNPs) efficiently catalyze the transformation of H2 O2 into oxygen gas. However, owing to the lack of an efficient approach or device that can measure the produced oxygen gas, the catalytic reaction has never been used for diagnostic applications. Microfluidics technology provides a platform that meets these requirements. The volumetric bar-chart chip (V-Chip) volumetrically measures the production of oxygen gas by PtNPs and can be integrated with ELISA technology to provide visible and quantitative readouts without expensive instrumentation or complicated data processing. Herein we show that PtNPs outperform catalase with respect to stability at high H2 O2 concentrations or temperatures or in long-term reactions, and are resistant to most catalase inhibitors. We also show that the catalase-like activity of PtNPs can be used in combination with the V-Chip to sensitively and specifically detect cancer biomarkers both in serum and on the cell surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.