Observational studyInternational forum of allergy & rhinology2014
Comparative effectiveness of medical and surgical therapy on olfaction in chronic rhinosinusitis: a prospective, multi-institutional study.
Observational study in International forum of allergy & rhinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- The Prevalence of Olfactory Dysfunction in the General Population: A Systematic Review and Meta-analysis.American journal of rhinology & allergy · 2021Pooled it
- Sino-Nasal outcome test-22 outcomes after sinus surgery: A systematic review and meta-analysis.The Laryngoscope · 2018Pooled it
- The prevalence of olfactory dysfunction in chronic rhinosinusitis.The Laryngoscope · 2017Pooled it
- Defining the minimal clinically important difference for olfactory outcomes in the surgical treatment of chronic rhinosinusitis.International forum of allergy & rhinology · 2017Trial
- Sensitivity analysis and diagnostic accuracy of the Brief Smell Identification Test in patients with chronic rhinosinusitis.International forum of allergy & rhinology · 2016Trial
- Health utility outcomes in patients undergoing medical management for chronic rhinosinusitis: a prospective multiinstitutional study.International forum of allergy & rhinology · 2015Trial
- Volumetric computed tomography analysis of the olfactory cleft in patients with chronic rhinosinusitis.International forum of allergy & rhinology · 2015Trial
- Investigation of change in cardinal symptoms of chronic rhinosinusitis after surgical or ongoing medical management.International forum of allergy & rhinology · 2015Trial
- Mechanisms, diagnosis, and treatment of olfactory dysfunction in rhinosinusitis.European journal of medical research · 2025Review
- Self-Reported Olfactory Outcomes in Transplanum and Transtuberculum Approaches.Journal of neurological surgery. Part B, Skull base · 2024Article
- Therapeutic Effectiveness of SNOT 22-Based Interdose Interval Adjustment of Dupilumab for Chronic Rhinosinusitis With Nasal Polyps.Clinical and experimental otorhinolaryngology · 2024Article
- [A longitudinal study of subjective olfactory function post-operatively in chronic rhinosinusitis patients with asthma and analysis of influencing factors].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Sense of smell in chronic rhinosinusitis: A multicentric study on 811 patients.Frontiers in allergy · 2023Article
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- [Olfactory and gustatory disorders].HNO · 2022Article
- Clinical potential of pupillary light reflex parameters as objective indicators reflecting chronic rhinosinusitis-specific quality of life: a 12-month prospective longitudinal study.Scientific reports · 2021Article
- Vascular permeability in chronic rhinosinusitis enhances accumulation and retention of nanoscale pegylated liposomes.Nanomedicine : nanotechnology, biology, and medicine · 2021Article
- Psychometric properties of the brief version of the questionnaire of olfactory disorders in patients with chronic rhinosinusitis.International forum of allergy & rhinology · 2021Article
- Endoscopic sinus surgery outcomes in CRS: quality of life and correlations with NOSE scale in a prospective cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Predicting olfactory loss in chronic rhinosinusitis using machine learning.Chemical senses · 2021Observational
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEvidence comparing the impact of medical and surgical management of chronic rhinosinusitis on olfactory function is limited. This study evaluates olfactory outcomes in patients who failed initial medical management and elect either continued medical management or endoscopic sinus surgery (ESS) followed by medical management.
methodsAdult subjects were prospectively enrolled into a nonrandomized, multi-institutional cohort. Baseline characteristics, quality-of-life and objective clinical findings were collected along with 2 quality-of-life disease-specific measures, the Rhinosinusitis Disability Index (RSDI) and Sinonasal Outcome Test (SNOT-22). The primary outcome measure was the posttreatment change (≥6 months) in the Brief Smell Identification Test (B-SIT). Bivariate and multivariate analyses compared B-SIT changes by treatment type while controlling for baseline cofactors.
resultsSubjects (n = 280) were enrolled between March 2011 and May 2013. Baseline B-SIT scores (mean ± standard deviation) were comparable between medical and surgical treatment groups (8.8 ± 3.2 vs 9.0 ± 3.2; p = 0.703). Subjects with baseline impaired olfaction (n = 83; 29.6%) experienced B-SIT improvement in both the medical (n = 17; 2.3 ± 2.8; p = 0.005) and surgical (n = 66; 2.1 ± 3.0; p < 0.001) cohort. A total of 38.6% of subjects with impaired olfaction return to normal olfaction at follow-up with no difference identified between treatment modalities (p = 0.803). Multivariate analyses identified prior surgery as a predictor of less improvement regardless of treatment modality in patients with baseline impaired olfaction. Average changes in B-SIT scores were comparable between treatment groups (p > 0.050).
conclusionSubjects electing ESS experienced gains in olfaction comparable to subjects electing continued medical management. Further study with larger sample size and more sensitive measures of olfaction are needed to determine differences between treatment groups.
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