Evidence map›Paper›PMID 25044634›Full record

ArticleMolecular nutrition & food research2014

Vitamin K catabolite inhibition of ovariectomy-induced bone loss: structure-activity relationship considerations.

Robin J Soper, Cenk Oguz, Roger Emery, Andrew A Pitsillides, Stephen J Hodges

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Robin J SoperComparative Biomedical Sciences, Royal Veterinary College, London, UK.
Cenk Oguz
Roger Emery
Andrew A Pitsillides
Stephen J Hodges
Royal Veterinary College · GBImperial College London · GB

Funding

Wellcome Trust 093234
6 · The paper itself

Abstract

scopeThe potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma-carboxylation of the vitamin K-dependent bone proteins. We therefore tested the hypothesis that vitamin K catabolites, 5-carbon (CAN5C) and 7-carbon carboxylic acid (CAN7C) aliphatic side-chain derivatives of the naphthoquinone moiety exert an osteotrophic role consistent with the treatment of osteoporosis. METHODS AND

resultsOsteoblast-like MG63 cell cultures were challenged with lipopolysaccharide and the levels of interleukin-6, an osteoclastogenic cytokine, measured with and without catabolites; low concentrations of CAN7C significantly inhibited interleukin-6 release, but CAN5C did not. In models of bone loss induced by ovariectomy or sciatic neurectomy in C57BL/6 mice, we found that the rarer CAN7C catabolite markedly restricted ovariectomy-induced bone loss and possibly limited sciatic neurectomy-induced bone loss. CAN7C activity depends on a free carboxylic acid and its particular side-chain structure.

conclusionThese in vivo data indicate for the first time that the clinical utility of vitamin K for osteoporosis may reside in an unusual catabolite.

Indexed as

Disease Models, AnimalAnimalsBone Density Conservation AgentsCarboxylic AcidsCell LineCell ProliferationDenervationFemaleHumansInjections, IntraperitonealInterleukin-6Interleukin-6 InhibitorsMethylationMice, Inbred C57BLMolecular StructureNaphthoquinonesBone Density Conservation AgentsCAN5C compoundCAN7C compoundCAN8C compoundCarboxylic AcidsIL6 protein, humanInterleukin-6Interleukin-6 InhibitorsNaphthoquinonesVitamin KBone lossCataboliteNaphthoquinoneOvariectomyVitamin K

Identifiers

PMID25044634
PMCPMC4826594
OpenAlexW2107519111

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.