Trial reportObesity (Silver Spring, Md.)2014
An abnormal lymphatic phenotype is associated with subcutaneous adipose tissue deposits in Dercum's disease.
Trial report in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Dercum's Disease: Bridging Present Understanding and Emerging Directions.Life (Basel, Switzerland) · 2026Review
- The Molecular Mechanisms Underlying Dercum's Disease: Exploring the Intersection of Obesity, Pain, and Inflammation.International journal of molecular sciences · 2025Review
- Imaging peripheral lymphatic dysfunction in chronic conditions.Frontiers in physiology · 2023Review
- Lymphatic function and anatomy in early stages of lipedema.Obesity (Silver Spring, Md.) · 2022Article
- Metabolic and immunological phenotype of rare lipomatoses: Dercum's disease and Roch-Leri mesosomatic lipomatosis.Orphanet journal of rare diseases · 2021Article
- Rare Forms of Lipomatosis: Dercum's Disease and Roch-Leri Mesosomatous Lipomatosis.Journal of clinical medicine · 2021Review
- Infections preceding the development of Dercum disease.IDCases · 2020Article
- Regulation of Lymphatic Function in Obesity.Frontiers in physiology · 2020Review
- The Role of Lymphatic Vascular Function in Metabolic Disorders.Frontiers in physiology · 2020Review
- Lipedema and Dercum's Disease: A New Application of Bioimpedance.Lymphatic research and biology · 2019Article
- Dercum's disease (adiposis dolorosa): a review of clinical presentation and management.Reumatologia · 2019Review
- Rare Presentation of Dercum's Disease in a Child with Abnormalities in Lipoprotein Metabolism.Arquivos brasileiros de cardiologia · 2018Article
- Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis.Nature reviews. Rheumatology · 2018Review
- Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema.Obesity (Silver Spring, Md.) · 2018Article
- [Lipedema: up-to-date of a long forgotten disease].Wiener medizinische Wochenschrift (1946) · 2017Review
- Hyperglycemia- and hyperinsulinemia-induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Differentiating lipedema and Dercum's disease.International journal of obesity (2005) · 2017Article
- Lipedema: A Relatively Common Disease with Extremely Common Misconceptions.Plastic and reconstructive surgery. Global open · 2016Article
- Lymphatic transport in patients with chronic venous insufficiency and venous leg ulcers following sequential pneumatic compression.Journal of vascular surgery. Venous and lymphatic disorders · 2016Article
- Juxta-articular adiposis dolorosa (Dercum's disease type IV): report of four cases and treatment by dermolipectomy.Wiener medizinische Wochenschrift (1946) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveInvestigational, near-infrared fluorescence (NIRF) lymphatic imaging was used to assess lymphatic architecture and contractile function in participants diagnosed with Dercum's disease, a rare, poorly understood disorder characterized by painful lipomas in subcutaneous adipose tissues.
methodsAfter informed consent and as part of an FDA-approved feasibility study to evaluate lymphatics in diseases in which their contribution has been implicated, three women diagnosed with Dercum's disease and four control subjects were imaged. Each participant received multiple intradermal and subcutaneous injections of indocyanine green (ICG, total dose ≤400 µg) in arms, legs, and/or trunk. Immediately after injection, ICG was taken up by the lymphatics and NIRF imaging was conducted.
resultsThe lymphatics in the participants with Dercum's disease were intact and dilated, yet sluggishly propelled lymph when compared to control lymphatics. Palpation of regions containing fluorescent lymphatic pathways revealed tender, fibrotic, tubular structures within the subcutaneous adipose tissue that were associated with painful nodules, and, in some cases, masses of fluorescent tissue indicating that some lipomas may represent tertiary lymphoid tissues.
conclusionsThese data support the hypothesis that Dercum's disease may be a lymphovascular disorder and suggest a possible association between abnormal adipose tissue deposition and abnormal lymphatic structure and function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.