ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2014
Aberrant parietal cortex developmental trajectories in girls with Turner syndrome and related visual-spatial cognitive development: a preliminary study.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Executive Functions in Children and Adolescents with Turner Syndrome: A Systematic Review and Meta-Analysis.Neuropsychology review · 2018Pooled it
- Turner Syndrome With 45,X/46,XX Mosaicism and a Derivative X Chromosome (Xqter → Xq13?::Xp11.4 → Xqter): A Case Report.Clinical case reports · 2025Article
- Syndrome-Specific Neuroanatomical Phenotypes in Girls With Turner and Noonan Syndromes.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Adolescent brain development in girls with Turner syndrome.Human brain mapping · 2023Article
- Sex Chromosome Dosage Effects on White Matter Structure in the Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Altered Brain Structure in Infants with Turner Syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Brain Development in School-Age and Adolescent Girls: Effects of Turner Syndrome, Estrogen Therapy, and Genomic Imprinting.Biological psychiatry · 2020Article
- X-Chromosome Insufficiency Alters Receptive Fields across the Human Early Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- PTPN11 Gain-of-Function Mutations Affect the Developing Human Brain, Memory, and Attention.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- X-Chromosome Effects on Attention Networks: Insights from Imaging Resting-State Networks in Turner Syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Normal Performance in Non-Visual Social Cognition Tasks in Women with Turner Syndrome.Frontiers in endocrinology · 2018Article
- Multi-Table Differential Correlation Analysis of Neuroanatomical and Cognitive Interactions in Turner Syndrome.Neuroinformatics · 2018Article
- Care of girls and women with Turner syndrome: beyond growth and hormones.Endocrine connections · 2017Review
- Attention deficit hyperactivity disorder (ADHD) in phenotypically similar neurogenetic conditions: Turner syndrome and the RASopathies.Journal of neurodevelopmental disorders · 2017Review
- Sex differences in amygdala shape: Insights from Turner syndrome.Human brain mapping · 2016Article
- Proceedings from the Turner Resource Network symposium: the crossroads of health care research and health care delivery.American journal of medical genetics. Part A · 2015Article
- Chiari I Malformation Associated with Turner Syndrome.Journal of neurosciences in rural practiceArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
Turner syndrome (TS) arises from partial or complete absence of the X-chromosome in females. Girls with TS show deficits in visual-spatial skills as well as reduced brain volume and surface area in the parietal cortex which supports these cognitive functions. Thus, measuring the developmental trajectory of the parietal cortex and the associated visual-spatial cognition in TS may provide novel insights into critical brain-behavior associations. In this longitudinal study, we acquired structural MRI data and assessed visual-spatial skills in 16 (age: 8.23 ± 2.5) girls with TS and 13 age-matched controls over two time-points. Gray and white matter volume, surface area and cortical thickness were calculated from surfaced based segmentation of bilateral parietal cortices, and the NEPSY Arrows subtest was used to assess visual-spatial ability. Volumetric and cognitive scalars were modeled to obtain estimates of age-related change. The results show aberrant growth of white matter volume (P = 0.011, corrected) and surface area (P = 0.036, corrected) of the left superior parietal regions during childhood in girls with TS. Other parietal sub-regions were significantly smaller in girls with TS at both time-points but did not show different growth trajectories relative to controls. Furthermore, we found that visual-spatial skills showed a widening deficit for girls with TS relative to controls (P = 0.003). Young girls with TS demonstrate an aberrant trajectory of parietal cortical and cognitive development during childhood. Elucidating aberrant neurodevelopmental trajectories in this population is critical for determining specific stages of brain maturation that are particularly dependent on TS-related genetic and hormonal factors.
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