ArticleHuman brain mapping2014
Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Role of White Matter Microstructure in Impulsive Behavior.The Journal of neuropsychiatry and clinical neurosciences · 2022Pooled it
- Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/NoGo task.Alcoholism, clinical and experimental research · 2014Trial
- Family History of Substance Use and Stressful Life Events Impact Adolescent Maturation of Cerebral White Matter.Addiction biology · 2025Article
- Increased white blood cell in young adults with family histories of alcohol and other substance use disorders.Addiction biology · 2024Article
- Early life adversity and increased antisocial and depressive tendencies in young adults with family histories of alcohol and other substance use disorders: Findings from the Family Health Patterns project.Addictive behaviors reports · 2022Article
- Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood.Frontiers in human neuroscience · 2022Article
- White Matter Microstructure in the Young Adult Brain Varies with Neighborhood Disadvantage in Adolescence.Neuroscience · 2021Article
- Neurobiological mechanisms of early life adversity, blunted stress reactivity and risk for addiction.Neuropharmacology · 2021Review
- Magnetic resonance spectroscopy studies of substance use disorders: Current landscape and potential future directions.Pharmacology, biochemistry, and behavior · 2021Review
- Abnormal structural brain network and hemisphere-specific changes in bulimia nervosa.Translational psychiatry · 2019Article
- Early life adversity and increased delay discounting: Findings from the Family Health Patterns project.Experimental and clinical psychopharmacology · 2019Article
- Miniature pig magnetic resonance spectroscopy model of normal adolescent brain development.Journal of neuroscience methods · 2018Article
- Miniature pig model of human adolescent brain white matter development.Journal of neuroscience methods · 2018Article
- Meat Consumption During Pregnancy and Substance Misuse Among Adolescent Offspring: Stratification of TCN2 Genetic Variants.Alcoholism, clinical and experimental research · 2017Article
- Association of White Matter With Core Cognitive Deficits in Patients With Schizophrenia.JAMA psychiatry · 2017Article
- Alcoholism and sexual dimorphism in the middle longitudinal fascicle: a pilot study.Brain imaging and behavior · 2017Article
- Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol.Brain and behavior · 2017Article
- White Matter Injury after Intracerebral Hemorrhage: Pathophysiology and Therapeutic Strategies.Frontiers in human neuroscience · 2017Review
- Discovery, Development, and Adoption of Medications to Treat Alcohol Use Disorder: Goals for the Phases of Medications Development.Alcoholism, clinical and experimental research · 2016Review
- Behavioral Impulsivity and Risk-Taking Trajectories Across Early Adolescence in Youths With and Without Family Histories of Alcohol and Other Drug Use Disorders.Alcoholism, clinical and experimental research · 2015Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Individuals with a family history of substance use disorder (FH+) show impaired frontal white matter as indicated by diffusion tensor imaging (DTI). This impairment may be due to impaired or delayed development of myelin in frontal regions, potentially contributing to this population's increased risk for developing substance use disorders. In this study, we examined high angular resolution DTI and proton magnetic resonance spectroscopy data from the anterior corona radiata were collected in 80 FH+ and 34 FH- youths (12.9 ± 1.0 years old). White matter integrity indices included fractional anisotropy (FA), N-acetylaspartate (NAA), and total choline (tCho). Lower FA suggests decreased myelination. Decreased NAA coupled with higher tCho suggests impaired build-up and maintenance of cerebral myelin and consequently greater breakdown of cellular membranes. We found FH+ youths had lower FA (P < 0.0001) and NAA (P = 0.017) and higher tCho (P = 0.04). FH density (number of parents and grandparents with substance use disorders) was negatively correlated with FA (P < 0.0001) and NAA (P = 0.011) and positively correlated with tCho (P = 0.001). FA was independently predicted by both FH density (P = 0.006) and NAA (P = 0.002), and NAA and tCho were both independent predictors of FH density (P < 0.001). Our finding of lower frontal FA in FH+ youths corresponding to lower NAA and increased tCho is consistent with delayed or impaired development of frontal white matter in FH+ youths. Longitudinal studies are needed to determine how these differences relate to substance use outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.