ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2014
The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.
Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- TOMM40 genetic variants associated with healthy aging and longevity: a systematic review.BMC geriatrics · 2022Pooled it
- The relationship between diabetes mellitus and attention deficit hyperactivity disorder: A systematic review and meta-analysis.Frontiers in pediatrics · 2022Pooled it
- Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes.Neurobiology of aging · 2023Article
- Attention Deficit Hyperactivity Disorder Misdiagnosis: Why Medical Evaluation Should Be a Part of ADHD Assessment.Brain sciences · 2023Article
- Executive Function and Diabetes: A Clinical Neuropsychology Perspective.Frontiers in psychology · 2020Review
- Biothiols and oxidative stress markers and polymorphisms ofOncotarget · 2018Article
- The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Review
- Warning SINEs: Alu elements, evolution of the human brain, and the spectrum of neurological disease.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018Review
- Prediction of Alzheimer's Disease-Associated Genes by Integration of GWAS Summary Data and Expression Data.Frontiers in genetics · 2018Article
- The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Characterization ofAlzheimer's & dementia (New York, N. Y.) · 2017Article
- The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Article
- Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort.PloS one · 2017Article
- Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults.Journal of the neurological sciences · 2016Article
- Potential contribution of the Alzheimer's disease risk locus BIN1 to episodic memory performance in cognitively normal Type 2 diabetes elderly.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Article
- A Genetics-based Biomarker Risk Algorithm for Predicting Risk of Alzheimer's Disease.Alzheimer's & dementia (New York, N. Y.) · 2016Article
- The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging.Journal of Parkinson's disease and Alzheimer's disease · 2014Article
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Authors and funding
12 authors at 5 institutions in 3 countries.
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Abstract
The variable length poly-T, rs10524523 ('523') located within the TOMM40 gene, was recently associated with several phenotypes of cognitive function. The short (S) allele is associated with later AD onset age and better cognitive performance, compared to the longer alleles (long and very-long (VL)). There is strong linkage disequilibrium between variants in the TOMM40 and APOE genes. In this study, we investigated the effect of '523' on cognitive performance in a sample of cognitively normal Jewish elderly with type 2 diabetes, a group at particularly high risk for cognitive impairment. Using a MANCOVA procedure, we compared homozygous carriers of the S/S allele (N=179) to carriers of the VL/VL allele (N=152), controlling for demographic and cardiovascular covariates. The S/S group performed better than the VL/VL group (p=0.048), specifically in the executive function (p=0.04) and episodic memory (p=0.050) domains. These results suggest that previous findings of an association of the TOMM40 short allele with better cognitive performance, independently from the APOE variant status, are pertinent to elderly with diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.