ReviewMagnetic resonance in medicine2015
Quantitative susceptibility mapping (QSM): Decoding MRI data for a tissue magnetic biomarker.
Review in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07759895 (Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in Schizophrenia), which is not on this map. Cited by 454 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in Schizophrenia
Who cites it
454 citing papers in PubMed, 2 syntheses or guidelines pooled it, 850 citations in OpenAlex.
- Iron accumulation in multiple sclerosis and implications for cognitive and clinical progression: a systematic review of advanced neuroimaging studies.Journal of neurology · 2026Pooled it
- Quantitative susceptibility mapping in multiple sclerosis: A systematic review and meta-analysis.NeuroImage. Clinical · 2024Pooled it
- A Generalized Approach to Solving Deep Learning-Based Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level Dependent Magnitude (QSM + qBOLD or QQ) for Oxygen Extraction Fraction (OEF) Mapping Across Diverse Acquisition Schemes.Magnetic resonance in medicine · 2026Article
- Association Between Deep Gray Matter Iron Deposition Dysregulation and Cognitive Performance in Type 2 Diabetes Mellitus Patients: A Quantitative Susceptibility Mapping Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Multimodal convergence is needed before inferring neuroaxonal injury in migraine.The journal of headache and pain · 2026Article
- Simultaneous 3-D Adiabatic TNMR in biomedicine · 2026Article
- Quantitative Susceptibility Mapping of Kidney Stones: An Ex Vivo MRI Phantom Study.Magnetic resonance in medicine · 2026Article
- Impact of Oral Cladribine on TSPO-PET-Measurable Immune Cell Activation in Multiple Sclerosis.Neurology and therapy · 2026Article
- Fully-Constrained Variable Projection for Water-Fat Models.Magnetic resonance in medicine · 2026Article
- Limbic-Predominant Cortical Magnetic Susceptibility Alterations Are Associated With Glycemic Dysregulation and Cognitive Performance in Type 2 Diabetes.CNS neuroscience & therapeutics · 2026Article
- An external reference to enable quantitative susceptibility mapping (QSM) in absolute terms: theoretical considerations, simulations, and experimental evaluation.Magma (New York, N.Y.) · 2026Article
- Distinct brain susceptibility alteration pattern in Parkinson's disease with drooling: evidence from quantitative susceptibility mapping.Quantitative imaging in medicine and surgery · 2026Article
- Robust phase unwrapping for Dixon magnetic resonance imaging multiresolution pixel clustering and local surface fitting.Quantitative imaging in medicine and surgery · 2026Article
- Advancing Quantitative Susceptibility Mapping With 2.5D Diffusion Models for Rapid Intracranial Hemorrhage Quantification.Magnetic resonance in medicine · 2026Article
- Hematoma Coagulation is Associated with Perihematoma Edema Volume in Patients with Acute Intracerebral Hemorrhage.Neurocritical care · 2026Article
- Beyond the brake: The subthalamic nucleus predominantly facilitates action in non-human primates.Progress in neurobiology · 2026Article
- Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- Submillimeter postmortem and in vivo diffusion and susceptibility magnetic resonance imaging to characterize cortical micro- and meso-structures.Research square · 2026Article
- Longitudinal changes of iron in the substantia nigra of early-stage Parkinson's disease.medRxiv : the preprint server for health sciences · 2026Article
- HFE genotype influences substantia nigra iron accumulation and Parkinson's disease progression.medRxiv : the preprint server for health sciences · 2026Article
394 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
In MRI, the main magnetic field polarizes the electron cloud of a molecule, generating a chemical shift for observer protons within the molecule and a magnetic susceptibility inhomogeneity field for observer protons outside the molecule. The number of water protons surrounding a molecule for detecting its magnetic susceptibility is vastly greater than the number of protons within the molecule for detecting its chemical shift. However, the study of tissue magnetic susceptibility has been hindered by poor molecular specificities of hitherto used methods based on MRI signal phase and T2* contrast, which depend convolutedly on surrounding susceptibility sources. Deconvolution of the MRI signal phase can determine tissue susceptibility but is challenged by the lack of MRI signal in the background and by the zeroes in the dipole kernel. Recently, physically meaningful regularizations, including the Bayesian approach, have been developed to enable accurate quantitative susceptibility mapping (QSM) for studying iron distribution, metabolic oxygen consumption, blood degradation, calcification, demyelination, and other pathophysiological susceptibility changes, as well as contrast agent biodistribution in MRI. This paper attempts to summarize the basic physical concepts and essential algorithmic steps in QSM, to describe clinical and technical issues under active development, and to provide references, codes, and testing data for readers interested in QSM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.