Evidence map›Paper›PMID 25043972›Full record

ReviewCancer2015

Subtyping of triple-negative breast cancer: implications for therapy.

Vandana G Abramson, Brian D Lehmann, Tarah J Ballinger, Jennifer A Pietenpol

Registry-linked trialAbstract readReview
In one paragraph

Review in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05843292 (Short-term Sintilimab in Combination With Taxane and Carboplatin for Neoadjuvant Therapy in Triple-negative Breast Cancer, an Open-labeled, Single Arm Trial), which is not on this map. Cited by 187 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05843292 phase4not yet recruitingnot on this mapstarted 2023, after this paper: background citation

Short-term Sintilimab in Combination With Taxane and Carboplatin for Neoadjuvant Therapy in Triple-negative Breast Cancer, an Open-labeled, Single Arm Trial

TypeinterventionalSponsorShanghai Jiao Tong University School of MedicineRan2023 to 2034Enrolled48ConditionsTriple-negative Breast CancerArmsTaxane and Carboplatin, Short-term Sintilimab, Surgery
3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Development and Evaluation of LiposomalPharmaceuticals (Basel, Switzerland) · 2025
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127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vandana G AbramsonDepartment of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Brian D Lehmann
Tarah J Ballinger
Jennifer A Pietenpol

Funding

TISSUE CoreP50CA098131 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PARK, BEN HO, PIETENPOL, JENNIFER A · 2003 to 2024
$48.7M
NCI NIH HHS CA95131NCI NIH HHS P50 CA098131
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is a heterogeneous disease; gene expression analyses recently identified 6 distinct TNBC subtypes, each of which displays a unique biology. Exploring novel approaches for the treatment of these subtypes is critical, especially because the median survival for women with metastatic TNBC is less than 12 months, and virtually all women with metastatic TNBC ultimately will die of their disease despite systemic therapy. To date, not a single targeted therapy has been approved for the treatment of TNBC, and cytotoxic chemotherapy remains the standard treatment. In this review, the authors discuss recent developments in subtyping TNBC and the current and upcoming therapeutic strategies being explored in an attempt to target TNBC.

Indexed as

Antineoplastic AgentsClinical Trials as TopicFemaleGene Expression Regulation, NeoplasticHumansMolecular Targeted TherapyTriple Negative Breast NeoplasmsAntineoplastic Agentsclinical trialssubtyping triple-negative breast cancertargeted therapiestriple-negative breast cancer

Identifiers

PMID25043972
PMCPMC4270831

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.