ArticleGenes, chromosomes & cancer2014
ZFP36-FOSB fusion defines a subset of epithelioid hemangioma with atypical features.
Article in Genes, chromosomes & cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 157 citations in OpenAlex.
- Article
- FOS gene fusions in osteosarcoma raise the hypothesis of malignant transformation of osteoblastoma.Virchows Archiv : an international journal of pathology · 2026Article
- Penile pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like hemangioendothelioma: a case report and literature review.Frontiers in oncology · 2026Article
- Subgroup of meningiomas involving FOS and FOSB gene fusions.Nature communications · 2025Article
- A cellular epithelioid hemangioma of the liver harboring a novel FOS::BCAR3 fusion gene.Virchows Archiv : an international journal of pathology · 2025Article
- Cutaneous Hemangioma With Epithelioid Features Harboring TPM3/4::ALK Fusions : A Distinct Entity or a Molecular Variant of Epithelioid Hemangioma?The American journal of surgical pathology · 2025Article
- Epithelioid hemangioma of the acromion causing shoulder pain: a case report.Clinics in shoulder and elbow · 2024Article
- YAP, TAZ, and Hippo-Dysregulating Fusion Proteins in Cancer.Annual review of cancer biology · 2024Article
- A cutaneous epithelioid vascular tumor harboring a TPM3::ALK fusion.Genes, chromosomes & cancer · 2024Article
- Extensive analysis of 59 sarcoma-related fusion genes identified pazopanib as a potential inhibitor to COL1A1-PDGFB fusion gene.Cancer science · 2023Article
- Genomic Profiling of the Craniofacial Ossifying Fibroma by Next-Generation Sequencing.Head and neck pathology · 2023Article
- Eccrine Poroma: Pathogenesis, New Diagnostic Tools and Association with Porocarcinoma-A Review.Diagnostics (Basel, Switzerland) · 2023Review
- The Recent Advances in Molecular Diagnosis of Soft Tissue Tumors.International journal of molecular sciences · 2023Review
- Recurrent FOSL1 rearrangements in desmoplastic fibroblastoma.The Journal of pathology · 2023Article
- ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma.Genes, chromosomes & cancer · 2022Article
- From FOS fusions to somatic mutations in the MAPK pathway, heterogeneous genetic abnormalities cause distinct pathophysiology among subsets of epithelioid haemangiomas.The British journal of dermatology · 2022Article
- Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Soft Tissue Tumors.Head and neck pathology · 2022Review
- The genetics of vascular tumours: an update.Histopathology · 2022Review
- Clinicopathologic and molecular features of vascular tumors in a series of 118 cases.American journal of translational research · 2022Article
- A unique epithelioid vascular neoplasm of bone characterized by EWSR1/FUS-NFATC1/2 fusions.Genes, chromosomes & cancer · 2021Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Epithelioid hemangioma (EH) is a benign neoplasm with distinctive vasoformative features, which occasionally shows increased cellularity, cytologic atypia, and/or loco-regional aggressive growth, resulting in challenging differential diagnosis from malignant vascular neoplasms. Based on two intraosseous EH index cases with worrisome histologic features, such as the presence of necrosis, RNA sequencing was applied for possible fusion gene discovery and potential subclassification of a novel atypical EH subset. A ZFP36-FOSB fusion was detected in one case, while a WWTR1-FOSB chimeric transcript in the other, both were further validated by fluorescence in situ hybridization (FISH) and reverse transcription polymerase chain reaction (RT-PCR). These abnormalities were then screened by FISH in 44 EH from different locations with seven additional EH revealing FOSB gene rearrangements, all except one being fused to ZFP36. Interestingly, 4/6 penile EH studied showed FOSB abnormalities. Although certain atypical histologic features were observed in the FOSB-rearranged EH, including solid growth, increased cellularity, mild to moderate nuclear pleomorphism, and necrosis in 3/9 cases, no overt sarcomatous areas were discerned to objectively separate the lesions from the fusion-negative EH. No patient has developed recurrence to date, but the follow-up was relatively limited and short to draw definitive conclusions regarding behavior. Although FOSB-rearranged EH do not show significant morphologic overlap with SERPINE1-FOSB fusion-positive pseudomyogenic hemangioendothelioma, FOSB oncogenic activation is emerging as an important event in these benign and intermediate groups of vascular tumors.
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