ArticleProteins2014
Expansion of the APC superfamily of secondary carriers.
Article in Proteins, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 96 citations in OpenAlex.
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- Structural and functional basis of proton-independent transition metal import by a canonical bacterial Nramp transporter.bioRxiv : the preprint server for biology · 2026Article
- Application of Protein Structure Encodings and Sequence Embeddings for Transporter Substrate Prediction.Molecules (Basel, Switzerland) · 2025Article
- Mosaic Evolution of Membrane Transporters in Galdieriales.Plants (Basel, Switzerland) · 2025Article
- Identification and Characterization of a Novel d-Branched-Chain Amino Acids Importer from Lactobacillus fermentum.Chembiochem : a European journal of chemical biology · 2025Article
- They all rock: A systematic comparison of conformational movements in LeuT-fold transporters.Structure (London, England : 1993) · 2024Article
- Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transporters.eLife · 2024Article
- Conservation of knotted and slipknotted topology in transmembrane transporters.Biophysical journal · 2023Article
- Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATBBiomolecules · 2022Article
- General principles of secondary active transporter function.Biophysics reviews · 2022Review
- Nramp: Deprive and conquer?Frontiers in cell and developmental biology · 2022Article
- Wheat potassium transporter TaHAK13 mediates KFrontiers in plant science · 2022Article
- Dormant spores sense amino acids through the B subunits of their germination receptors.Nature communications · 2021Article
- Rush Hour of LATs towards Their Transport Cycle.Membranes · 2021Review
- Molecular Mechanisms for Bacterial Potassium Homeostasis.Journal of molecular biology · 2021Review
- Molecular Mechanism of Nramp-Family Transition Metal Transport.Journal of molecular biology · 2021Review
- Microbial methionine transporters and biotechnological applications.Applied microbiology and biotechnology · 2021Review
- Insights into the mechanisms of transport and regulation of the arabidopsis high-affinity K+ transporter HAK51.Plant physiology · 2021Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The amino acid-polyamine-organoCation (APC) superfamily is the second largest superfamily of secondary carriers currently known. In this study, we establish homology between previously recognized APC superfamily members and proteins of seven new families. These families include the PAAP (Putative Amino Acid Permease), LIVCS (Branched Chain Amino Acid:Cation Symporter), NRAMP (Natural Resistance-Associated Macrophage Protein), CstA (Carbon starvation A protein), KUP (K⁺ Uptake Permease), BenE (Benzoate:H⁺ Virginia Symporter), and AE (Anion Exchanger). The topology of the well-characterized human Anion Exchanger 1 (AE1) conforms to a UraA-like topology of 14 TMSs (12 α-helical TMSs and 2 mixed coil/helical TMSs). All functionally characterized members of the APC superfamily use cation symport for substrate accumulation except for some members of the AE family which frequently use anion:anion exchange. We show how the different topologies fit into the framework of the common LeuT-like fold, defined earlier (Proteins. 2014 Feb;82(2):336-46), and determine that some of the new members contain previously undocumented topological variations. All new entries contain the two 5 or 7 TMS APC superfamily repeat units, sometimes with extra TMSs at the ends, the variations being greatest within the CstA family. New, functionally characterized members transport amino acids, peptides, and inorganic anions or cations. Except for anions, these are typical substrates of established APC superfamily members. Active site TMSs are rich in glycyl residues in variable but conserved constellations. This work expands the APC superfamily and our understanding of its topological variations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.