ArticleBMC genomics2014
Elucidating how the saprophytic fungus Aspergillus nidulans uses the plant polyester suberin as carbon source.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- FAMeDB: A Curated Database for the Analysis of Fungal Aromatic Compound Metabolism.Computational and structural biotechnology journal · 2026Article
- Diversity of Fungi Associated with Diseases of Cultivated Brassicaceae in Southern Italy.Journal of fungi (Basel, Switzerland) · 2025Article
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- Article
- Lipids and Lipid-Mediated Signaling in Plant-Pathogen Interactions.International journal of molecular sciences · 2024Review
- Review
- Article
- Visualization of Suberization and Lignification in Sugarcane.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Phylogenetic analysis and in-depth characterization of functionally and structurally diverse CE5 cutinases.The Journal of biological chemistry · 2021Article
- Gene family expansions and transcriptome signatures uncover fungal adaptations to wood decay.Environmental microbiology · 2021Article
- The sugarcane ShMYB78 transcription factor activates suberin biosynthesis in Nicotiana benthamiana.Plant molecular biology · 2020Article
- Identification of a dioxin-responsive oxylipin signature in roots of date palm: involvement of a 9-hydroperoxide fatty acid reductase, caleosin/peroxygenase PdPXG2.Scientific reports · 2018Article
- Comparative systems analysis of the secretome of the opportunistic pathogen Aspergillus fumigatus and other Aspergillus species.Scientific reports · 2018Article
- Physical, Chemical and Proteomic Evidence of Potato Suberin Degradation by the Plant Pathogenic Bacterium Streptomyces scabiei.Microbes and environments · 2016Article
- Proteome Analyses of Soil Bacteria Grown in the Presence of Potato Suberin, a Recalcitrant Biopolymer.Microbes and environments · 2016Article
- Characterization of the Far Transcription Factor Family in Aspergillus flavus.G3 (Bethesda, Md.) · 2016Article
- Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans.BMC genomics · 2016Article
- Suberin Regulates the Production of Cellulolytic Enzymes in Streptomyces scabiei, the Causal Agent of Potato Common Scab.Microbes and environments · 2015Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipid polymers in plant cell walls, such as cutin and suberin, build recalcitrant hydrophobic protective barriers. Their degradation is of foremost importance for both plant pathogenic and saprophytic fungi. Regardless of numerous reports on fungal degradation of emulsified fatty acids or cutin, and on fungi-plant interactions, the pathways involved in the degradation and utilisation of suberin remain largely overlooked. As a structural component of the plant cell wall, suberin isolation, in general, uses harsh depolymerisation methods that destroy its macromolecular structure. We recently overcame this limitation isolating suberin macromolecules in a near-native state.
resultsSuberin macromolecules were used here to analyse the pathways involved in suberin degradation and utilisation by Aspergillus nidulans. Whole-genome profiling data revealed the complex degrading enzymatic machinery used by this saprophytic fungus. Initial suberin modification involved ester hydrolysis and ω-hydroxy fatty acid oxidation that released long chain fatty acids. These fatty acids were processed through peroxisomal β-oxidation, leading to up-regulation of genes encoding the major enzymes of these pathways (e.g. faaB and aoxA). The obtained transcriptome data was further complemented by secretome, microscopic and spectroscopic analyses.
conclusionsData support that during fungal growth on suberin, cutinase 1 and some lipases (e.g. AN8046) acted as the major suberin degrading enzymes (regulated by FarA and possibly by some unknown regulatory elements). Suberin also induced the onset of sexual development and the boost of secondary metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.