ArticleThe Journal of comparative neurology2014
Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Genetic deletion of zinc transporter ZnTFrontiers in molecular neuroscience · 2024Article
- Neuronal signalling of zinc: from detection and modulation to function.Open biology · 2022Review
- MicroRNA-206 down-regulated human umbilical cord mesenchymal stem cells alleviate cognitive decline in D-galactose-induced aging mice.Cell death discovery · 2022Article
- Genetic removal of synaptic ZnFrontiers in neurology · 2022Article
- Neurobiology of zinc and its role in neurogenesis.European journal of nutrition · 2021Review
- Adverse Maternal Environment Alters MicroRNA-10b-5p Expression and Its Epigenetic Profile Concurrently with Impaired Hippocampal Neurogenesis in Male Mouse Hippocampus.Developmental neuroscience · 2021Article
- Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus.Stem cells (Dayton, Ohio) · 2020Article
- A NeurotoxicFrontiers in molecular neuroscience · 2020Review
- Zinc transporters in Alzheimer's disease.Molecular brain · 2019Review
- MeCP2 Deficiency Disrupts Kainate-Induced Presynaptic Plasticity in the Mossy Fiber Projections in the Hippocampus.Frontiers in cellular neuroscience · 2019Article
- The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice.Scientific reports · 2018Article
- Neurobiology of local and intercellular BDNF signaling.Pflugers Archiv : European journal of physiology · 2017Review
- Recombinant human brain-derived neurotrophic factor prevents neuronal apoptosis in a novel in vitro model of subarachnoid hemorrhage.Neuropsychiatric disease and treatment · 2017Article
- Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity.Neural plasticity · 2017Review
- Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation.Scientific reports · 2016Article
- Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus.Frontiers in cellular neuroscience · 2015Review
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The neurotrophin receptor, TrkB receptor tyrosine kinase, is critical to central nervous system (CNS) function in health and disease. Elucidating the ligands mediating TrkB activation in vivo will provide insights into its diverse roles in the CNS. The canonical ligand for TrkB is brain-derived neurotrophic factor (BDNF). A diversity of stimuli also can activate TrkB in the absence of BDNF, a mechanism termed transactivation. Zinc, a divalent cation packaged in synaptic vesicles along with glutamate in axons of mammalian cortical neurons, can transactivate TrkB in neurons and heterologous cells in vitro. Yet the contributions of BDNF and zinc to TrkB activation in vivo are unknown. To address these questions, we conducted immunohistochemical (IHC) studies of the hippocampal mossy fiber axons and boutons using an antibody selective for pY816 of TrkB, a surrogate measure of TrkB activation. We found that conditional deletion of BDNF resulted in a reduction of pY816 in axons and synaptic boutons of hippocampal mossy fibers, thereby implicating BDNF in activation of TrkB in vivo. Unexpectedly, pY816 immunoreactivity was increased in axons but not synaptic boutons of mossy fibers in ZnT3 knockout mice that lack vesicular zinc. Marked increases of BDNF content were evident within the hippocampus of ZnT3 knockout mice and genetic elimination of BDNF reduced pY816 immunoreactivity in these mice, implicating BDNF in enhanced TrkB activation mediated by vesicular zinc depletion. These findings support the conclusion that BDNF but not vesicular zinc activates TrkB in hippocampal mossy fiber axons under physiological conditions.
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