Evidence map›Paper›PMID 25043691›Full record

ArticlePlacenta2014

Midregional pro-adrenomedullin plasma concentrations are blunted in severe preeclampsia.

B C Matson, R W Corty, N O Karpinich, A P Murtha, W Valdar, C A Grotegut, K M Caron

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Cardiovascular biomarkers and preeclampsia: A narrative review.European journal of clinical investigation · 2026
    Review
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  15. Adrenomedullin in lymphangiogenesis: from development to disease.Cellular and molecular life sciences : CMLS · 2015
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

B C MatsonDepartments of Cell Biology & Physiology, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: brooke_matson@med.unc.edu.
R W CortyDepartments of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: robert_corty@med.unc.edu.
N O KarpinichDepartments of Cell Biology & Physiology, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: karpinic@email.unc.edu.
A P MurthaDivision of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: murth002@mc.duke.edu.
W ValdarDepartments of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: william.valdar@unc.edu.
C A GrotegutDivision of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: chad.grotegut@duke.edu.
K M CaronDepartments of Cell Biology & Physiology, University of North Carolina at Chapel Hill, NC 27599, USA; Departments of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: kathleen_caron@med.unc.edu.
University of North Carolina at Chapel Hill · USDuke University · US

Funding

Adrenomedullin Signaling at the Maternal-Fetal InterfaceR01HD060860 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Caron · 2009 to 2026
$4.8M
UNC Predoc Training Progr in Bioinformatics/Comp BiologyT32GM067553 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELSTON, TIMOTHY C · 2005 to 2019
$2.5M
NICHD NIH HHS HD060860NICHD NIH HHS R01 HD060860NIGMS NIH HHS T32 GM067553
6 · The paper itself

Abstract

Levels of the peptide hormone adrenomedullin (AM) are elevated during normal pregnancy, but whether this differs during complications of pregnancy remains unresolved. AM can be quantified by measuring its pre-prohormone byproduct, midregional pro-adrenomedullin (MR-proADM). MR-proADM has shown prognostic value as a biomarker of heart failure, sepsis, and community-acquired pneumonia. Given the relevance of AM to pregnancy, we tested the hypothesis that MR-proADM provides a biomarker for preeclampsia. We find that MR-proADM plasma concentrations are blunted in severe preeclampsia and that MR-proADM is similarly effective as established biomarkers endoglin and placental growth factor at discriminating patients with severe preeclampsia from controls.

Indexed as

AdrenomedullinAdultBiomarkersCase-Control StudiesFemaleHumansPre-EclampsiaPregnancyProtein PrecursorsYoung AdultAdrenomedullinBiomarkersproadrenomedullinProtein PrecursorsAdrenomedullinMidregional pro-adrenomedullinPreeclampsiaPregnancy

Identifiers

PMID25043691
PMCPMC4143458
OpenAlexW1988490659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.