Evidence map›Paper›PMID 25043640›Full record

ArticleLung cancer (Amsterdam, Netherlands)2014

Polymorphisms of peroxisome proliferator-activated receptors and survival of lung cancer and upper aero-digestive tract cancers.

Ying Yang, Rita V Burke, Christie Y Jeon, Shen-Chih Chang, Po-Yin Chang, Hal Morgenstern, Donald P Tashkin, Jenny Mao, Wendy Cozen, Thomas M Mack and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung cancer (Amsterdam, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-δ Pathway.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Ying YangDepartment of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA.
Rita V BurkePediatric Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA; Division of Pediatric Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Christie Y JeonCancer Prevention and Genetics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Shen-Chih ChangDepartment of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA.
Po-Yin ChangDepartment of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA; Division of Endocrinology, Gerontology, & Metabolism, School of Medicine, Stanford University, Stanford, CA, USA; VA Palo Alto Health Care System, Palo Alto, CA, USA.
Hal MorgensternDepartments of Epidemiology, Environmental Health Sciences, and Urology, Schools of Public Health and Medicine, and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Donald P TashkinDivision of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Jenny MaoPulmonary and Critical Care Section, New Mexico VA Healthcare System, Albuquerque, NM, USA.
Wendy CozenDepartment of Preventive Medicine, USC Keck School of Medicine at University of Southern California, Los Angeles, CA, USA.
Thomas M MackDepartment of Preventive Medicine, USC Keck School of Medicine at University of Southern California, Los Angeles, CA, USA.
Jianyu RaoDepartment of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA; Department of Pathology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Zuo-Feng ZhangDepartment of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA. Electronic address: zfzhang@ucla.edu.
University of California, Los Angeles · USUniversity of Southern California · USCedars-Sinai Medical Center · USNew Mexico VA Health Care System · USUniversity of Michigan · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA SPORE IN LUNG CANCERP50CA090388 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2001 to 2008
$13.0M
UCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3M
Stem Cell Selection &Expansion Via HOX Gene ActivationR01CA090833 · NCI · UNIVERSITY OF PENNSYLVANIA · PI EMERSON, STEPHEN G · 2001 to 2010
$2.6M
MARIJUANA USE AND THE RISKS OF LUNG AND OTHER CANCERSR01DA011386 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORGENSTERN, HAL M · 1999 to 2003
$1.8M
Molecular Epidemiology and Gene-Environment InteractionR21ES011667 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 2002 to 2004
$651k
NCI NIH HHS CA09142NCI NIH HHS CA90833NCI NIH HHS P30 CA016042NCI NIH HHS P50 CA090388NCI NIH HHS R01 CA090833NCI NIH HHS T32 CA009142NIDA NIH HHS DA11386NIDA NIH HHS R01 DA011386NIEHS NIH HHS ES011667NIEHS NIH HHS R21 ES011667
6 · The paper itself

Abstract

backgroundPeroxisome proliferator-activated receptors (PPARs) are transcriptional factors involved in several biological processes such as inflammation, cancer growth, progression and apoptosis that are important in lung and upper aero-digestive tract (UADT) cancer outcomes. Nonetheless, there are no published studies of the relationship between PPARs gene polymorphisms and survival of patients with lung cancer or UADT cancers.

methods1212 cancer patients (611 lung, 303 oral, 100 pharyngeal, 90 laryngeal, and 108 esophageal) were followed for a median duration of 11 years. We genotyped three potentially functional single nucleotide polymorphisms (SNPs) using Taqman - rs3734254 of the gene PPARD and rs10865710 and rs1801282 of the gene PPARG - and investigated their associations with lung and UADT cancer survival using Cox regression. A semi-Bayesian shrinkage approach was used to reduce the potential for false positive findings when examining multiple associations.

resultsThe variant homozygote CC (vs. TT) of PPARD rs3734254 was inversely associated with mortality of both lung cancer (adjusted hazard ratio [aHR]=0.63, 95% confidence interval [CI]=0.42, 0.96) and UADT cancers (aHR=0.51, 95% CI=0.27, 0.99). Use of the semi-Bayesian shrinkage approach yielded a posterior aHR for lung cancer of 0.66 (95% posterior limits=0.44, 0.98) and a posterior aHR for UADT cancers of 0.58 (95% posterior limits=0.33, 1.03).

conclusionOur findings suggest that lung-cancer patients with the CC variant of PPARD rs3734254 may have a survival advantage over lung-cancer patients with other gene variants.

Indexed as

Polymorphism, GeneticAdultAgedAllelesFemaleFollow-Up StudiesGene-Environment InteractionGenotypeHead and Neck NeoplasmsHumansLung NeoplasmsMaleMiddle AgedNeoplasm GradingPeroxisome Proliferator-Activated ReceptorsPolymorphism, Single NucleotidePeroxisome Proliferator-Activated ReceptorsLung cancerPeroxisome proliferator-activated receptorsSingle nucleotide polymorphismSurvivalUpper aero-digestive tract cancers

Identifiers

PMID25043640
PMCPMC4143535
OpenAlexW1971280051

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.