Evidence map›Paper›PMID 25043585›Full record

ArticleVirology2014

Conservation in China of a novel group of HCV variants dating to six centuries ago.

Yuling An, Tao Wu, Min Wang, Ling Lu, Chunhua Li, Yuanpin Zhou, Yongshui Fu, Guihua Chen

Open access · greenAbstract read
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  5. [An evolutionary analysis of HCV genotype 6 in Li people in Hainan Province, China].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2017
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Yuling AnDepartment of Liver Transplantation, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
Tao WuDepartment of Infectious Disease, Southern Medical University, Guangzhou, Guangdong 510515, China; Department of Infectious Disease, Hainan General Hospital, Haikou, Hainan 570311, China.
Min WangGuangzhou Blood Center, Guangzhou, Guangdong 510095, China.
Ling LuDepartment of Liver Transplantation, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China; Center for Viral Oncology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA. Electronic address: llu@kumc.edu.
Chunhua LiCenter for Viral Oncology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Yuanpin ZhouDepartment of Infectious Disease, Southern Medical University, Guangzhou, Guangdong 510515, China.
Yongshui FuGuangzhou Blood Center, Guangzhou, Guangdong 510095, China.
Guihua ChenDepartment of Liver Transplantation, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
Guangzhou Blood Center · CNSun Yat-sen University · CNUniversity of Kansas · USHainan General Hospital · CNSouthern Medical University · CN

Funding

HCV Genotype 6: A Model for HCV Genetics and Molecular Epidemiology StudiesR01AI080734 · NIAID · UNIVERSITY OF UTAH · PI LU, LING · 2009 to 2011
$1.1M
NIAID NIH HHS 5 R01 AI080734-03ANIAID NIH HHS R01 AI080734
6 · The paper itself

Abstract

unlabelledWe characterized a novel group of HCV variants that are genetically related but distinct from each other belonging to genotype 6 (HCV-6). From 26 infected Austronesian-descended aborigines on Hainan Island, China, HCV sequences were determined followed by genetic analyses. Six nearly full-length genomes and 20 E1 sequences of HCV were obtained, which differ from each other and from all known HCV lineages by nucleotides above the intra-subtype level of 13%. Together with subtypes 6g and 6w, they constitute a phylogenetic group sharing a common ancestor dating from the end of the 12th century.

conclusionOur data indicate the maintenance of an isolated HCV-6 indigenous circulation on Hainan Island at least for six centuries.

Indexed as

Evolution, MolecularGenetic VariationBase SequenceGenome, ViralHepacivirusHepatitis CHumansMolecular Sequence DataPhylogenyAustronesian aboriginesChinaEvolutionHainan IslandHCV genotype 6

Identifiers

PMID25043585
PMCPMC4186720
OpenAlexW2074303399

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.