Evidence map›Paper›PMID 25043380›Full record

ArticleJournal of the International AIDS Society2014

Maximizing the benefits of antiretroviral therapy for key affected populations.

Ian R Grubb, Sarah W Beckham, Michel Kazatchkine, Ruth M Thomas, Eliot R Albers, Mauro Cabral, Joep Lange, Stefano Vella, Manoj Kurian, Chris Beyrer and 1 more

Abstract read
In one paragraph

Article in Journal of the International AIDS Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ian R GrubbCenter for Public Health and Human Rights, Johns Hopkins University, Baltimore, MD, USA.
Sarah W BeckhamDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA; sarah.beckham@jhu.edu.
Michel KazatchkineUN, Geneva, Switzerland.
Ruth M ThomasGlobal Network of Sex Work Projects, Edinburgh, United Kingdom.
Eliot R AlbersInternational Network of People Who Use Drugs, London, United Kingdom.
Mauro CabralGlobal Action for Trans* Equality, Buenos Aires, Argentina.
Joep LangeAmsterdam Institute of Global Health and Development, Amsterdam, The Netherlands.
Stefano VellaDepartment of Therapeutics, HIV, Hepatitis and Global Health, Istituto Superiore di Sanità, Rome, Italy.
Manoj KurianInternational AIDS Society, Geneva, Switzerland.
Chris BeyrerDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
IAS Treatment for Key Affected Populations Working Group

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Johns Hopkins HIV Epidemiology and Prevention Sciences Training ProgramT32AI102623 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Shruti H Mehta · 2013 to 2026
$5.3M
NIAID NIH HHS P30 AI094189NIAID NIH HHS T32 AI102623NIAID NIH HHS T32AI102623
6 · The paper itself

Abstract

introductionScientific research has demonstrated the clinical benefits of earlier initiation of antiretroviral treatment (ART), and that ART can markedly reduce HIV transmission to sexual partners. Ensuring universal access to ART for those who need it has long been a core principle of the HIV response, and extending the benefits of ART to key populations is critical to increasing the impact of ART and the overall effectiveness of the HIV response. However, this can only be achieved through coordinated efforts to address political, social, legal and economic barriers that key populations face in accessing HIV services. DISCUSSION: Recent analyses show that HIV prevalence levels among key populations are far higher than among the general population, and they experience a range of biological and behavioural factors, and social, legal and economic barriers that increase their vulnerability to HIV and have resulted in alarmingly low ART coverage. World Health Organization 2014 consolidated guidance on HIV among key populations offers the potential for increased access to ART by key populations, following the same principles as for the general adult population. However, it should not be assumed that key populations will achieve greater access to ART unless stigma, discrimination and punitive laws, policies and practices that limit access to ART and other HIV interventions in many countries are addressed.

conclusionsRights-based approaches and investments in critical enablers, such as supportive legal and policy environments, are essential to enable wider access to ART and other HIV interventions for key populations. The primary objective of ART should always be to treat the person living with HIV; prevention is an important, additional benefit. ART should be provided only with informed consent. The preventive benefits of treatment must not be used as a pretext for failure to provide other necessary HIV programming for key populations, including comprehensive harm reduction and other prevention interventions tailored to meet the needs of key populations. An end to AIDS is only possible if we overcome the barriers of criminalization, stigma and discrimination that remain key drivers of the HIV epidemics among key populations.

Indexed as

Health Services AccessibilityAdultAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveDisease Transmission, InfectiousFemaleGlobal HealthGuidelines as TopicHealth PolicyHIV InfectionsHumansMaleTime FactorsWorld Health OrganizationAnti-Retroviral AgentsHIV/AIDShuman rightstreatment

Identifiers

PMID25043380
PMCPMC4104298

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.