Evidence map›Paper›PMID 25043177›Full record

ArticleCell reports2014

The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.

Mark A McCormick, Amanda G Mason, Stephan J Guyenet, Weiwei Dang, Renee M Garza, Marc K Ting, Rick M Moller, Shelley L Berger, Matt Kaeberlein, Lorraine Pillus and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. UPS writes a new saga of SAGA.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023
    Review
  3. TheAging · 2023
    Article
  4. Genomic Instability and Epigenetic Changes during Aging.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Nuclear mRNA Export and Aging.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Review
  11. New Insights into the Role of Histone Changes in Aging.International journal of molecular sciences · 2020
    Review
  12. Review
  13. Review
  14. Review
  15. Molecular Targets and Therapeutic Strategies in Spinocerebellar Ataxia Type 7.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Epigenetic changes during aging and their reprogramming potential.Critical reviews in biochemistry and molecular biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Mark A McCormickBuck Institute for Research on Aging, Novato, CA 94945, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Amanda G MasonDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Stephan J GuyenetDepartment of Medical Genetics, University of Washington, Seattle, WA 98195, USA.
Weiwei DangDepartment of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 76798, USA.
Renee M GarzaDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; University of California, San Diego, Moores Cancer Center, La Jolla, CA 92093, USA.
Marc K TingBuck Institute for Research on Aging, Novato, CA 94945, USA.
Rick M MollerDepartment of Pathology, University of Washington, Seattle, WA 98195, USA.
Shelley L BergerDepartment of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Matt KaeberleinDepartment of Pathology, University of Washington, Seattle, WA 98195, USA.
Lorraine PillusUniversity of California, San Diego, Moores Cancer Center, La Jolla, CA 92093, USA; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
Albert R La SpadaDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Medical Genetics, University of Washington, Seattle, WA 98195, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: alaspada@ucsd.edu.
Brian K KennedyBuck Institute for Research on Aging, Novato, CA 94945, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. Electronic address: bkennedy@buckinstitute.org.
University of Washington · USUniversity of California, San Diego · USUniversity of Pennsylvania · USBuck Institute for Research on Aging · USSanford Consortium for Regenerative Medicine · USUniversity of Washington Medical Center · US

Funding

Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
SCA7 RETINAL DEGENERATION: MOLECULAR BASIS &THERAPYR01EY014061 · NEI · UNIVERSITY OF WASHINGTON · PI ALBERT R LA SPADA · 2002 to 2026
$8.4M
Nutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4M
Molecular genetic regulation of autophagy in health and neurodegenerative diseaseR01AG033082 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LA SPADA, ALBERT R · 2009 to 2019
$4.0M
System approaches to determine mechanisms underlying yeast replicative agingR01AG043080 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI KENNEDY, BRIAN K · 2012 to 2016
$3.0M
FUNCTIONAL ANALYSIS OF THE SIR2 SILENCING PROTEINR01GM054778 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI PILLUS, LORRAINE · 1997 to 2005
$1.5M
Defining the Mechanisms of genotype-dependent responses to caloric restrictionR01AG039390 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT · 2011 to 2015
$1.5M
Genome-wide Analysis of Aging in YeastR01AG025549 · NIA · UNIVERSITY OF WASHINGTON · PI KENNEDY, BRIAN K · 2006 to 2010
$1.5M
Chromatin Regulation by Deacetylation and SUMO-Targeted Ubiquitin LigationR01GM090177 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PILLUS, LORRAINE · 2009 to 2012
$1.3M
Regulation of yeast cellular aging through chromatin and novel pathwaysR00AG037646 · NIA · BAYLOR COLLEGE OF MEDICINE · PI DANG, WEIWEI · 2013 to 2015
$740k
Identification of STUbL substrates critical for cell growth and regulationF32GM089101 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARZA, RENEE M · 2009 to 2011
$151k
NEI NIH HHS R01 EY014061NHLBI NIH HHS T32 HL007028NIA NIH HHS R00 AG037646NIA NIH HHS R01 AG025549NIA NIH HHS R01 AG033082NIA NIH HHS R01 AG039390NIA NIH HHS R01 AG043080NIA NIH HHS T32 AG000266NIGMS NIH HHS F32 GM089101NIGMS NIH HHS GM054778NIGMS NIH HHS GM090177NIGMS NIH HHS R01 GM054778NIGMS NIH HHS R01 GM090177NIGMS NIH HHS T32 GM008666NIGMS NIH HHS T32 GM008666-14
6 · The paper itself

Abstract

We have analyzed the yeast replicative lifespan of a large number of open reading frame (ORF) deletions. Here, we report that strains lacking genes SGF73, SGF11, and UBP8 encoding SAGA/SLIK complex histone deubiquitinase module (DUBm) components are exceptionally long lived. Strains lacking other SAGA/SALSA components, including the acetyltransferase encoded by GCN5, are not long lived; however, these genes are required for the lifespan extension observed in DUBm deletions. Moreover, the SIR2-encoded histone deacetylase is required, and we document both a genetic and physical interaction between DUBm and Sir2. A series of studies assessing Sir2-dependent functions lead us to propose that DUBm strains are exceptionally long lived because they promote multiple prolongevity events, including reduced rDNA recombination and altered silencing of telomere-proximal genes. Given that ataxin-7, the human Sgf73 ortholog, causes the neurodegenerative disease spinocerebellar ataxia type 7, our findings indicate that the genetic and epigenetic interactions between DUBm and SIR2 will be relevant to neurodegeneration and aging.

Indexed as

DNA ReplicationCell ProliferationEndopeptidasesHistone Acetyltransferasesp300-CBP-Associated FactorProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeSirtuin 2Trans-ActivatorsEndopeptidasesGCN5 protein, S cerevisiaeHistone Acetyltransferasesp300-CBP-Associated FactorSaccharomyces cerevisiae ProteinsSAGA complex, S cerevisiaeSgf73 protein, S cerevisiaeSilent Information Regulator Proteins, Saccharomyces cerevisiaeSIR2 protein, S cerevisiaeSirtuin 2Trans-ActivatorsUBP8 protein, S cerevisiae

Identifiers

PMID25043177
PMCPMC4284099
OpenAlexW2008326047

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.