Trial reportThe Journal of allergy and clinical immunology2014
Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy.
Trial report in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Sublingual Immunotherapy: How Sublingual Allergen Administration Heals Allergic Diseases; Current Perspective about the Mode of Action.Pathogens (Basel, Switzerland) · 2021Review
- Article
- Experimental validation of the RATE tool for inferring HLA restrictions of T cell epitopes.BMC immunology · 2017Article
- Molecular fingerprinting of complex grass allergoids: size assessments reveal new insights in epitope repertoires and functional capacities.The World Allergy Organization journal · 2017Article
- Immunodominance in allergic T-cell reactivity to Japanese cedar in different geographic cohorts.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Article
- Sequence conservation predicts T cell reactivity against ragweed allergens.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- T-cell epitope conservation across allergen species is a major determinant of immunogenicity.The Journal of allergy and clinical immunology · 2016Article
- Distinct modulation of allergic T cell responses by subcutaneous vs. sublingual allergen-specific immunotherapy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- Different Bla-g T cell antigens dominate responses in asthma versus rhinitis subjects.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
- Definition of a pool of epitopes that recapitulates the T cell reactivity against major house dust mite allergens.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
- A population response analysis approach to assign class II HLA-epitope restrictions.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Allergy-associated T cell epitope repertoires are surprisingly diverse and include non-IgE reactive antigens.The World Allergy Organization journal · 2014Review
- New strategies for allergen T cell epitope identification: going beyond IgE.International archives of allergy and immunology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDifferent populations of T cells are involved in the pathogenesis of allergic diseases.
objectiveWe investigated changes in TH-cell populations in patients with allergies after specific immunotherapy (SIT).
methodsPBMCs were isolated from patients with allergies who received SIT and those who did not (controls). We tested the ability of peptides from 93 timothy grass (TG) proteins to induce T-cell responses (cytokine production). We used ELISPOT and staining assays for intracellular cytokines to measure the production of IL-4, IL-5, IL-13, IFN-γ, and IL-10.
resultsCompared with PBMCs from controls, PBMCs from patients who received SIT produced lower levels of TH2 cytokines on incubation with several different TG peptides. These data were used to select 20 peptides to be tested in an independent cohort of 20 patients with allergies who received SIT and 20 controls. We again observed a significant decrease in the production of TH2 cytokines, and an increase in the production of the TH1 cytokine IFN-γ, in PBMCs from the validation groups. These changes correlated with improved symptoms after SIT. Immunization with this selected pool of peptides (or their associated antigens) could protect a substantial proportion of the population from TG allergy.
conclusionsWe observed a significant decrease in the production of TH2 cytokines by PBMCs from patients who received SIT for TG allergy compared to those who did not. These changes might be used to monitor response to therapy. The decrease occurred in response to antigens that elicit little (if any) IgE responses; these antigens might be developed for use in immunotherapy.
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