SynthesisAnnals of neurology2014
Genetic association signal near NTN4 in Tourette syndrome.
Synthesis in Annals of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome.Translational psychiatry · 2023Pooled it
- Investigation of gene-environment interactions in relation to tic severity.Journal of neural transmission (Vienna, Austria : 1996) · 2021Pooled it
- Can polygenic risk scores help explain disease prevalence differences around the world? A worldwide investigation.BMC genomic data · 2023Article
- Copy Number Variations in Children with Tourette Syndrome: Systematic Investigation in a Clinical Setting.Genes · 2023Article
- Common targetable inflammatory pathways in brain transcriptome of autism spectrum disorders and Tourette syndrome.Frontiers in neuroscience · 2022Article
- Article
- Association of GDNF and CNTNAP2 gene variants with gambling.Journal of behavioral addictions · 2019Article
- Concordance of genetic variation that increases risk for tourette syndrome and that influences its underlying neurocircuitry.Translational psychiatry · 2019Article
- Immunity in Gilles de la Tourette-Syndrome: Results From a Cerebrospinal Fluid Study.Frontiers in neurology · 2019Article
- European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents.European child & adolescent psychiatry · 2019Article
- Perinatal risk factors in Tourette's and chronic tic disorders: a total population sibling comparison study.Molecular psychiatry · 2018Article
- Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach.European archives of psychiatry and clinical neuroscience · 2018Article
- Tourette syndrome: a disorder of the social decision-making network.Brain : a journal of neurology · 2018Review
- Progress in Genetic Studies of Tourette's Syndrome.Brain sciences · 2017Review
- Genetic Approaches to Understanding Psychiatric Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Article
- Editorial: The Neurobiology and Genetics of Gilles de la Tourette Syndrome: New Avenues through Large-Scale Collaborative Projects.Frontiers in psychiatry · 2017Article
- Investigation of SNP rs2060546 Immediately Upstream toFrontiers in neuroscience · 2016Article
- Meta-Analysis of Tourette Syndrome and Attention Deficit Hyperactivity Disorder Provides Support for a Shared Genetic Basis.Frontiers in neuroscience · 2016Article
- Recent Advances in Understanding and Managing Tourette Syndrome.F1000Research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 20 institutions in 11 countries.
Funding
Abstract
Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10(-3) ) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10(-4) ) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10(-7) ). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case-control status (p = 0.042), suggesting that many of these variants are true TS risk alleles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.