ArticleHepatology (Baltimore, Md.)2014
Superior survival using living donors and donor-recipient matching using a novel living donor risk index.
Article in Hepatology (Baltimore, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07383194 (A Clinically Applicable Prediction Model for Living Donor Liver Transplantation Outcomes Using the International LDLT Registry), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Clinically Applicable Prediction Model for Living Donor Liver Transplantation Outcomes Using the International LDLT Registry
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Meta-analysis and meta-regression of outcomes for adult living donor liver transplantation versus deceased donor liver transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Pooled it
- The International Liver Transplantation Society Living Donor Liver Transplant Recipient Guideline.Transplantation · 2017Guideline
- Uterus transplantation in the United States: analysis of patients and early postoperative outcomes in the national organ procurement and transplantation network.Frontiers in transplantation · 2026Article
- Impact of graft type on outcomes following liver transplantation for primary sclerosing cholangitis.Hepatology international · 2025Article
- Association between low fasting glucose of the living donor and risk of graft loss in the recipient after liver transplantation.Scientific reports · 2025Article
- Review
- Living-Donor Liver Transplant and Improved Post-Transplant Survival in Patients with Primary Sclerosing Cholangitis.Journal of clinical medicine · 2023Article
- Maximizing utility of nondirected living liver donor grafts using machine learning.Frontiers in immunology · 2023Article
- Treatment of primary sclerosing cholangitis in children.World journal of hepatology · 2019Review
- Living donor liver transplantation: eliminating the wait for death in end-stage liver disease?Nature reviews. Gastroenterology & hepatology · 2017Review
- Acute Rejection Increases Risk of Graft Failure and Death in Recent Liver Transplant Recipients.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2017Observational
- Underutilization of Living Donor Liver Transplantation in the United States: Bias against MELD 20 and Higher.Journal of clinical and translational hepatology · 2016Article
- Recurrent primary sclerosing cholangitis in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study: Comparison of risk factors between living and deceased donor recipients.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2016Article
- Living donor liver transplantation in the USA.Hepatobiliary surgery and nutrition · 2016Review
- Liver transplant center variability in accepting organ offers and its impact on patient survival.Journal of hepatology · 2016Article
- Liver Transplantation for Cholestatic Liver Diseases in Adults.Clinics in liver disease · 2016Review
- Liver Transplant in Patients With Primary Sclerosing Cholangitis.Gastroenterology & hepatology · 2016Article
- Defining long-term outcomes with living donor liver transplantation in North America.Annals of surgery · 2015Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledThe deceased-donor organ supply in the U.S. has not been able to keep pace with the increasing demand for liver transplantation. We examined national Organ Procurement and Transplantation Network/United Network for Organ Sharing (OPTN/UNOS) data from 2002-2012 to assess whether living donor liver transplantation (LDLT) has surpassed deceased donor liver transplantation (DDLT) as a superior method of transplantation, and used donor and recipient characteristics to develop a risk score to optimize donor and recipient selection for LDLT. From 2002-2012, there were 2,103 LDLTs and 46,674 DDLTs that met the inclusion criteria. The unadjusted 3-year graft survival for DDLTs was 75.5% (95% confidence interval [CI]: 75.1-76.0%) compared with 78.9% (95% CI: 76.9-80.8%; P<0.001) for LDLTs that were performed at experienced centers (>15 LDLTs), with substantial improvement in LDLT graft survival over time. In multivariate models, LDLT recipients transplanted at experienced centers with either autoimmune hepatitis or cholestatic liver disease had significantly lower risks of graft failure (hazard ratio [HR]: 0.56, 95% CI: 0.37-0.84 and HR: 0.76, 95% CI: 0.63-0.92, respectively). An LDLT risk score that included both donor and recipient variables facilitated stratification of LDLT recipients into high, intermediate, and low-risk groups, with predicted 3-year graft survival ranging from >87% in the lowest risk group to <74% in the highest risk group.
conclusionCurrent posttransplant outcomes for LDLT are equivalent, if not superior, to DDLT when performed at experienced centers. An LDLT risk score can be used to optimize LDLT outcomes and provides objective selection criteria for donor selection in LDLT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.