ReviewNatural product reports2014
The ever-expanding role of asymmetric covalent organocatalysis in scalable, natural product synthesis.
Review in Natural product reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Article
- Recent Advances in the Domino Annulation Reaction of Quinone Imines.Molecules (Basel, Switzerland) · 2024Review
- The synthesis of pharmacologically important oxindolesRSC advances · 2023Article
- Organocatalytic Asymmetric Peroxidation of γ,δ-Unsaturated β-Keto Esters-A Novel Route to Chiral Cycloperoxides.Molecules (Basel, Switzerland) · 2023Article
- Asymmetric and Site-Selective [3 + 2]-Annulations for the Synthesis of High-Value Bicyclic Lactams.Organic letters · 2018Article
- Synthesis, Characterization, and Computational Modeling of N-(1-Ethoxyvinyl)pyridinium Triflates, an Unusual Class of Pyridinium Salts.Molecules (Basel, Switzerland) · 2018Article
- Stereodivergent, Diels-Alder-initiated organocascades employing α,β-unsaturated acylammonium salts: scope, mechanism, and application.Chemical science · 2017Article
- Enantioselective Stereodivergent Nucleophile-Dependent Isothiourea-Catalysed Domino Reactions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Asymmetric Organocatalysis: The Emerging Utility of α,β-Unsaturated Acylammonium Salts.Angewandte Chemie (International ed. in English) · 2016Review
- Oxadendralenes in asymmetric organocatalysis for the construction of tetrahydroisochromenes.Chemical science · 2016Article
- Asymmetric N-Heterocyclic Carbene Catalyzed Annulation of 2-Alkenylbenzothiazoles with α-Chloro Aldehydes.Synthesis · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Following the turn of the millennium, the role of asymmetric covalent organocatalysis has developed into a scalable, synthetic paradigm galvanizing the synthetic community toward utilization of these methods toward more practical, metal-free syntheses of natural products. A myriad of reports on asymmetric organocatalytic modes of substrate activation relying on small, exclusively organic molecules are delineating what has now become the multifaceted field of organocatalysis. In covalent catalysis, the catalyst and substrate combine to first form a covalent, activated intermediate that enters the catalytic cycle. Following asymmetric bond formation, the chiral catalyst is recycled through hydrolysis or displacement by a pendant group on the newly formed product. Amine- and phosphine-based organocatalysts are the most common examples that have led to a vast array of reaction types. This Highlight provides a brief overview of covalent modes of organocatalysis and applications of scalable versions of these methods applied to the total synthesis of natural products including examples from our own laboratory.
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Registered trials
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