ArticleBiopolymers2014
A combined small-angle X-ray and neutron scattering study of the structure of purified soluble gastrointestinal mucins.
Article in Biopolymers, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Synthetic Mucins as Glycan-Defined Prebiotics.ACS central science · 2025Article
- Measuring the multifaceted roles of mucin-domain glycoproteins in cancer.Advances in cancer research · 2023Review
- Molecular Dynamics Simulations to Explore the Structure and Rheological Properties of Normal and Hyperconcentrated Airway Mucus.Studies in applied mathematics (Cambridge, Mass.) · 2021Article
- A Microscopically Motivated Model for Particle Penetration into Swollen Biological Networks.Polymers · 2020Article
- In Vitro Reconstitution of an Intestinal Mucus Layer Shows That Cations and pH Control the Pore Structure That Regulates Its Permeability and Barrier Function.ACS applied bio materials · 2020Article
- The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH.Scientific reports · 2019Article
- Mucus, mucins, and cystic fibrosis.Pediatric pulmonology · 2019Review
- Mucin gel assembly is controlled by a collective action of non-mucin proteins, disulfide bridges, CaScientific reports · 2018Article
- Secondary Structure and Glycosylation of Mucus Glycoproteins by Raman Spectroscopies.Analytical chemistry · 2016Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The structures of purified soluble porcine gastric (Muc5ac) and duodenal (Muc2) mucin solutions at neutral and acidic pH were examined using small-angle X-ray scattering and small-angle neutron scattering experiments. We provide evidence for the morphology of the network above the semidilute overlap concentration and above the entanglement concentration. Furthermore, we investigated the gelation of both types of mucin solutions in response to a reduction in pH, where we observed the formation of large-scale heterogeneities within the polymer solutions, typical of microphase-separated gels. The concentration dependence of the inhomogeneity length scale (Ξ) and the amplitude of the excess scattering intensity [I(ex) (0)] are consistent with previously studied gelled synthetic polymeric systems. The persistence lengths of the chains were found to be similar for both Muc5ac and Muc2 from Kratky plots of the neutron data (8 ± 2 nm).
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Registered trials
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