Evidence map›Paper›PMID 25041704›Full record

ArticleDiagnostic microbiology and infectious disease2014

Intestinal decontamination of multidrug-resistant Klebsiella pneumoniae after recurrent infections in an immunocompromised host.

Matthew P Kronman, Danielle M Zerr, Xuan Qin, Janet Englund, Cathy Cornell, Jean E Sanders, Jeffrey Myers, Jaipreet Rayar, Jessica E Berry, Amanda L Adler and 1 more

Registry-linked trialOpen access · greenAbstract readCase Reports
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06156956 (Fecal Microbiota Transplantation to Eradicate Antibiotic-resistance Bacteria From the Gastrointestinal Tract of Patients at High Risk of Infection and/or to Cut Off the Spread of Bacteria With Dangerous Mechanisms of Antibiotic Resistance), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06156956 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Fecal Microbiota Transplantation to Eradicate Antibiotic-resistance Bacteria From the Gastrointestinal Tract of Patients at High Risk of Infection and/or to Cut Off the Spread of Bacteria With Dangerous Mechanisms of Antibiotic Resistance

TypeinterventionalSponsorHuman Biome Institute S.A.Ran2023 to 2025Enrolled200ConditionsDrug Resistance, Bacterial, Antimicrobial Drug ResistanceArmsFecal Microbiota Transplantation
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Matthew P KronmanDepartment of Pediatrics, University of Washington, Seattle, WA, USA; Division of Infectious Diseases, University of Washington, Seattle, WA, USA; Center for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA. Electronic address: matthew.kronman@seattlechildrens.org.
Danielle M ZerrDepartment of Pediatrics, University of Washington, Seattle, WA, USA; Division of Infectious Diseases, University of Washington, Seattle, WA, USA; Center for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
Xuan QinMicrobiology laboratory, Seattle Children's Hospital, Seattle, WA, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.
Janet EnglundDepartment of Pediatrics, University of Washington, Seattle, WA, USA; Division of Infectious Diseases, University of Washington, Seattle, WA, USA; Center for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
Cathy CornellDivision of Infectious Diseases, University of Washington, Seattle, WA, USA.
Jean E SandersDivision of Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jeffrey MyersCenter for Childhood Infections and Prematurity Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
Jaipreet RayarCenter for Childhood Infections and Prematurity Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
Jessica E BerryCenter for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
Amanda L AdlerCenter for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
Scott J WeissmanDepartment of Pediatrics, University of Washington, Seattle, WA, USA; Division of Infectious Diseases, University of Washington, Seattle, WA, USA.
Seattle Children's Hospital · USUniversity of Washington · USFred Hutch Cancer Center · US

Funding

National surveillance of emerging MDR in pediatric Enterobacteriaceae infectionsR01AI083413 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI WEISSMAN, SCOTT J, ZERR, DANIELLE M · 2010 to 2013
$2.3M
NIAID NIH HHS R01 AI083413NIAID NIH HHS R01AI083413
6 · The paper itself

Abstract

Multidrug-resistant (MDR) Enterobacteriaceae infections are associated with increased morbidity. We describe a 20-year-old hematopoietic cell transplantation recipient with recurrent MDR Klebsiella pneumoniae infection, prolonged intestinal colonization, and subsequent intestinal decontamination. Further study should evaluate stool surveillance, molecular typing, and fecal microbiota transplantation for patients with intestinal MDR Enterobacteriaceae carriage.

Indexed as

AdultAnti-Bacterial AgentsBacteremiaDrug Resistance, Multiple, BacterialFecesHematopoietic Stem Cell TransplantationHumansImmunocompromised HostKlebsiella InfectionsKlebsiella pneumoniaeMaleRecurrenceSkin Diseases, BacterialTransplant RecipientsYoung AdultAnti-Bacterial AgentsHematopoietic cell transplantationIntestinal decontaminationKlebsiella pneumoniaePediatricsResistance

Identifiers

PMID25041704
PMCPMC4162817
OpenAlexW2151056434

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.