ArticleAddiction (Abingdon, England)2014
Genetic variation in personality traits explains genetic overlap between borderline personality features and substance use disorders.
Article in Addiction (Abingdon, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Borderline personality disorder and substance use disorder: a clinical and psychopathological investigation.BMC psychiatry · 2026Article
- Article
- Affective Factors in the Co-Occurrence of Personality Disorders and Substance Use Disorders.Current addiction reports · 2026Review
- Review
- A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease.Current atherosclerosis reports · 2024Review
- Are Borderline Personality Disorder Features Differentially Related to Pre-Incarceration Alcohol, Cannabis, Cocaine, and Opioid Dependence Among People Recently Incarcerated in Jail?Journal of personality disorders · 2022Article
- Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness.Translational psychiatry · 2022Article
- Genetics of substance use disorders in the era of big data.Nature reviews. Genetics · 2021Review
- Total and cause-specific mortality in patients with personality disorders: the association between comorbid severe mental illness and substance use disorders.Social psychiatry and psychiatric epidemiology · 2021Article
- Alcohol use patterns and disorders among individuals with personality disorders in the Sao Paulo Metropolitan Area.PloS one · 2021Article
- Comparing the potential causal influence of two indicators of early alcohol use on later alcohol use disorder symptoms.Journal of abnormal psychology · 2020Article
- Big Five personality traits and alcohol, nicotine, cannabis, and gambling disorder comorbidity.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019Article
- Manifesto for a European research network into Problematic Usage of the Internet.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2018Article
- Associations between personality disorders and cannabis use and cannabis use disorder: a population-based twin study.Addiction (Abingdon, England) · 2018Article
- Associations Between Divorce and Onset of Drug Abuse in a Swedish National Sample.American journal of epidemiology · 2018Article
- Propofol sedation during gastrointestinal endoscopy arouses euphoria in a large subset of patients.United European gastroenterology journal · 2018Article
- The Development and Validation of the Bergen-Yale Sex Addiction Scale With a Large National Sample.Frontiers in psychology · 2018Article
- Prediction of alcohol use disorder using personality disorder traits: a twin study.Addiction (Abingdon, England) · 2018Observational
- Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.Nature genetics · 2018Article
- Borderline personality disorder and substance use disorders: an updated review.Borderline personality disorder and emotion dysregulation · 2018Review
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Authors and funding
7 authors.
Funding
Abstract
aimsTo examine the genetic overlap between borderline personality features (BPF) and substance use disorders (SUDs) and the extent to which variation in personality traits contributes to this covariance.
designGenetic structural equation modelling was used to partition the variance in and covariance between personality traits, BPF and SUDs into additive genetic, shared and individual-specific environmental factors.
settingAll participants were registered with the Australian Twin Registry.
participantsA total of 3127 Australian adult twins participated in the study. MEASUREMENTS: Diagnoses of DSM-IV alcohol and cannabis abuse/dependence (AAD; CAD) and nicotine dependence (ND) were derived via computer-assisted telephone interview. BPF and five-factor model personality traits were derived via self-report questionnaires.
findingsPersonality traits, BPF and substance use disorders were partially influenced by genetic factors with heritability estimates ranging from 0.38 (neuroticism; 95% confidence interval: 0.30-0.45) to 0.78 (CAD; 95% confidence interval: 0.67-0.86). Genetic and individual-specific environmental correlations between BPF and SUDs ranged from 0.33 to 0.56 (95% CI = 0.19-0.74) and 0.19-0.32 (95% CI = 0.06-0.43), respectively. Overall, there was substantial support for genetic influences that were specific to AAD, ND and CAD (30.76-68.60%). Finally, genetic variation in personality traits was responsible for 11.46% (extraversion for CAD) to 59.30% (neuroticism for AAD) of the correlation between BPF and SUDs.
conclusionsBoth genetic and individual-specific environmental factors contribute to comorbidity between borderline personality features and substance use disorders. A substantial proportion of this comorbidity can be attributed to variation in normal personality traits, particularly neuroticism.
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