ArticleAddiction (Abingdon, England)2014
The impact of methadone maintenance therapy on hepatitis C incidence among illicit drug users.
Article in Addiction (Abingdon, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 4 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Pooled it
- Needle and syringe programmes and opioid substitution therapy for preventing HCV transmission among people who inject drugs: findings from a Cochrane Review and meta-analysis.Addiction (Abingdon, England) · 2018Pooled it
- Needle syringe programmes and opioid substitution therapy for preventing hepatitis C transmission in people who inject drugs.The Cochrane database of systematic reviews · 2017Pooled it
- Recommendations for the management of hepatitis C virus infection among people who inject drugs.The International journal on drug policy · 2015Guideline
- Video directly observed therapy for patients receiving office-based buprenorphine - A pilot randomized controlled trial.Drug and alcohol dependence · 2021Trial
- Low Hepatitis C Reinfection Following Direct-acting Antiviral Therapy Among People Who Inject Drugs on Opioid Agonist Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Trial
- Intensive Models of Hepatitis C Care for People Who Inject Drugs Receiving Opioid Agonist Therapy: A Randomized Controlled Trial.Annals of internal medicine · 2019Trial
- Integrated Studies of Infectious Disease Elimination (InSIDE): Hepatitis C Antibody and RNA Status of Persons Who Inject Drugs in New York State, 2021-2023.Journal of viral hepatitis · 2026Article
- Prevalence and Factors Associated With Hepatitis C in Danish Prisons, 2022-2024: A Multicentre Cross-Sectional Study.Journal of viral hepatitis · 2026Article
- Care strategies for pregnant people and women living with hepatitis C in North America.AJOG global reports · 2026Article
- Hepatitis C virus incidence trend and its risk factors among people who inject drugs in Hai Phong, Vietnam.Hepatology international · 2025Article
- Methadone and Buprenorphine as Medication for Addiction Treatment Diversely Affect Inflammation and Craving Depending on Their Doses.Pharmacy (Basel, Switzerland) · 2025Article
- "I still can feel the sickness": Withdrawal experiences of people on methadone maintenance treatment.Journal of substance use and addiction treatment · 2025Article
- The Impact of Current Opioid Agonist Therapy on Hepatitis C Virus Treatment Initiation Among People Who Use Drugs From the Direct-acting Antiviral (DAA) Era: A Population-Based Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Lessons from the First Wave of COVID-19 for Improved Medications for Opioid Use Disorder (MOUD) Treatment: Benefits of Easier Access, Extended Take Homes, and New Delivery Modalities.Substance use & misuse · 2022Article
- Article
- Treatment trajectories and barriers in opioid agonist therapy for people who inject drugs in rural Puerto Rico.Journal of substance abuse treatment · 2021Article
- A chance to do it better: Methadone maintenance treatment in the age of Covid-19.Journal of substance abuse treatment · 2021Article
- Prevalence and Medication Treatment of Opioid Use Disorder Among Primary Care Patients with Hepatitis C and HIV.Journal of general internal medicine · 2021Observational
- Patients at a drug detoxification center share perspectives on how to increase hepatitis C treatment uptake: A qualitative study.Drug and alcohol dependence · 2021Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
aimsTo determine the relationship between methadone maintenance therapy (MMT) and hepatitis C (HCV) seroconversion among illicit drug users.
designA generalized estimating equation model assuming a binomial distribution and a logit-link function was used to examine for a possible protective effect of MMT use on HCV incidence.
settingData from three prospective cohort studies of illicit drug users in Vancouver, Canada between 1996 and 2012.
participantsA total of 1004 HCV antibody-negative illicit drug users stratified by exposure to MMT. MEASUREMENTS: Baseline and semi-annual HCV antibody testing and standardized interviewer-administered questionnaire soliciting self-reported data relating to drug use patterns, risk behaviors, detailed socio-demographic data and status of active participation in an MMT program.
findingsOne hundred and eighty-four HCV seroconversions were observed for an HCV incidence density of 6.32 [95% confidence interval (CI) = 5.44-7.31] per 100 person-years. After adjusting for potential confounders, MMT exposure was protective against HCV seroconversion [adjusted odds ratio (AOR) = 0.47; 95% CI = 0.29-0.76]. In subanalyses, a dose-response protective effect of increasing MMT exposure on HCV incidence (AOR = 0.87; 95% CI = 0.78-0.97) per increasing 6-month period exposed to MMT was observed.
conclusionParticipation in methadone maintenance treatment appears to be highly protective against hepatitis C incidence among illicit drug users. There appears to be a dose-response protective effect of increasing methadone exposure on hepatitis C incidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.