Evidence map›Paper›PMID 25040830›Full record

ReviewMolecular microbiology2014

The ins and outs of bacterial iron metabolism.

Elaine R Frawley, Ferric C Fang

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 208 citations in OpenAlex.

  1. Article
  2. Microbiology spectrum · 2026
    Article
  3. Article
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  10. Article
  11. Article
  12. Review
  13. Akkermansia muciniphila MucNature communications · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Applied and environmental microbiology · 2025
    Article

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elaine R FrawleyDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Ferric C Fang
University of Washington · US

Funding

THE SALMONELLA TYPHIMURIUM SIGMAE REGULONR01AI044486 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 1999 to 2016
$4.9M
NITRIC OXIDE CYTOTOXICITY IN SALMONELLOSISR01AI039557 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 1997 to 2012
$4.1M
Iron Homeostasis in Salmonella-Host InteractionsR01AI077629 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2009 to 2010
$780k
Citrate and Metal Efflux by IceTF32AI112101 · NIAID · UNIVERSITY OF WASHINGTON · PI FRAWLEY, ELAINE R. · 2014 to 2016
$135k
MECHANISMS OF NITRIC OXIDE CYTOTOXICITY IN SALMONELLOSISR21AI039557 · NIAID · UNIVERSITY OF COLORADO DENVER · PI FANG, FERRIC C · 1996 to 1996
–
NIAID NIH HHS AI112101NIAID NIH HHS AI39557NIAID NIH HHS AI44486NIAID NIH HHS AI77629NIAID NIH HHS F32 AI112101NIAID NIH HHS R01 AI039557NIAID NIH HHS R01 AI044486NIAID NIH HHS R01 AI077629
6 · The paper itself

Abstract

Iron is a critical nutrient for the growth and survival of most bacterial species. Accordingly, much attention has been paid to the mechanisms by which host organisms sequester iron from invading bacteria and how bacteria acquire iron from their environment. However, under oxidative stress conditions such as those encountered within phagocytic cells during the host immune response, iron is released from proteins and can act as a catalyst for Fenton chemistry to produce cytotoxic reactive oxygen species. The transitory efflux of free intracellular iron may be beneficial to bacteria under such conditions. The recent discovery of putative iron efflux transporters in Salmonella enterica serovar Typhimurium is discussed in the context of cellular iron homeostasis.

Indexed as

HomeostasisAnimalsHost-Pathogen InteractionsHumansIronSalmonella InfectionsSalmonella typhimuriumIron

Identifiers

PMID25040830
PMCPMC4135372
OpenAlexW1892583423

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.