ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging
Carotid MRI Detection of Intraplaque Hemorrhage at 3T and 1.5T.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT03507374. Cited by 18 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostics Accuracy of Magnetic Resonance Imaging in Detection of Atherosclerotic Plaque Characteristics in Carotid Arteries Compared to Histology: A Systematic Review.Journal of magnetic resonance imaging : JMRI · 2025Pooled it
- Use of oral anticoagulant drugs is associated with carotid intraplaque hemorrhage in atherosclerosis patients: a meta-analysis.Journal of thrombosis and thrombolysis · 2019Pooled it
- Role of T1-weighted MRI in Identifying Coronary Intraplaque Hemorrhage: CATCH the Truly High-Risk Plaque.Journal of atherosclerosis and thrombosis · 2026Review
- Optimizing MPRAGE for enhanced blood suppression and intraplaque hemorrhage detection in carotid artery imaging.Magnetic resonance imaging · 2025Article
- Evaluation of methemoglobin as an intravascular contrast agent: T1 relaxation time effect in a rabbit model.Magnetic resonance imaging · 2023Article
- Carotid artery plaque characteristics: current reporting practices on CT angiography.Neuroradiology · 2021Observational
- Cervical Carotid Plaque MRI : Review of Atherosclerosis Imaging Features and their Histologic Underpinnings.Clinical neuroradiology · 2021Review
- Optimal Carotid Plaque Features on Computed Tomography Angiography Associated With Ischemic Stroke.Journal of the American Heart Association · 2021Article
- Quantification of Carotid Intraplaque Hemorrhage: Comparison between Manual Segmentation and Semi-Automatic Segmentation on Magnetization-Prepared Rapid Acquisition with Gradient-Echo Sequences.Diagnostics (Basel, Switzerland) · 2019Article
- Methemoglobin Modulation as an Intravascular Contrast Agent for Magnetic Resonance Imaging: Proof of Concept.Frontiers in veterinary science · 2019Article
- Superficial and multiple calcifications and ulceration associate with intraplaque hemorrhage in the carotid atherosclerotic plaque.European radiology · 2018Article
- Article
- Age-Specific Sex Differences in Magnetic Resonance Imaging-Depicted Carotid Intraplaque Hemorrhage.Stroke · 2017Article
- Motion-insensitive carotid intraplaque hemorrhage imaging using 3D inversion recovery preparation stack of stars (IR-prep SOS) technique.Journal of magnetic resonance imaging : JMRI · 2017Article
- Magnetic Resonance Imaging Detection of Intraplaque Hemorrhage.Magnetic resonance insights · 2017 · on this mapReview
- Vitamin D and Vulnerable Carotid Plaque.AJNR. American journal of neuroradiology · 2016Article
- Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA.AJNR. American journal of neuroradiology · 2016Article
- Correlation of Carotid Intraplaque Hemorrhage and Stroke Using 1.5 T and 3 T MRI.Magnetic resonance insights · 2015Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
background and purposeCarotid intraplaque hemorrhage leads to plaque progression and ischemic events. Detection can be accomplished with 3T T1w sequences, but may be limited by false-positive lipid/necrosis. The purpose of this study was threefold: (1) to determine if magnetization-prepared rapid acquisition with gradient-echo (MPRAGE) detects intraplaque hemorrhage versus lipid/necrosis; (2) if 3T MPRAGE image quality is retained at 1.5T; and (3) to determine observer agreement.
methodsMPRAGE positive areas were compared to hemorrhage and lipid/necrosis areas from 100 carotid endarterectomy slides in 12 subjects using multivariable linear regression. Image quality was determined between 3T and 1.5T in 716 carotid arteries using t-tests and multivariable linear regression. Kappa analysis was used to determine agreement.
resultsIntraplaque hemorrhage, not lipid/necrosis, was a significant predictor of MPRAGE positive area before and after adjusting for confounders (slope = .52 vs. .51, P < .001). Image quality at 3T was slightly lower than 1.5T (mean 3.87 vs. 4.34, P < .0001). 3T image quality remained slightly decreased before and after adjusting for confounders (slope = -.46 vs. -.41, P < .001). Kappa values for inter-/intraobserver agreement were .807/.919 at 3T and .803/.871 at 1.5T.
conclusionsCarotid MPRAGE detects intraplaque hemorrhage, not lipid/necrosis. 3T image quality was retained at 1.5T with very good observer agreement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.