Evidence map›Paper›PMID 25040591›Full record

ArticleAlcoholism, clinical and experimental research2014

Nicotinic acid supplementation in the context of alcoholic liver injury: friend or foe?

Kusum K Kharbanda

Abstract readComment
PubMed Publisher
In one paragraph

Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kusum K KharbandaResearch Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska; Departments of Internal Medicine and Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.
VA Nebraska Western Iowa Health Care System · US

Funding

Effect of Alcohol on Hepatic Creatine Biosynthesis: Role of Defective MethylationI01BX001155 · VA · OMAHA VA MEDICAL CENTER · PI KHARBANDA, KUSUM K. · 2012 to 2015
–
BLRD VA I01 BX001155
6 · The paper itself

Abstract

Li and colleagues (2014) in this issue report that dietary nicotinic acid (NA) supplementation ameliorates ethanol-induced hepatic steatosis, but a deficiency does not worsen injury induced by alcohol alone. The authors further present some mechanistic insights into the protective role of NA supplementation. Results of this and other previous studies in the context of alcoholic liver injury raise one important question as to what should be an adequate dose of NA that will provide the maximum benefit to hepatic and extrahepatic tissues and with minimum adverse effects.

Indexed as

Dietary SupplementsAnimalsEthanolFatty Liver, AlcoholicMaleNiacinEthanolNiacinEthanolHepaticMethylation PotentialNiacinPrevention

Identifiers

PMID25040591
OpenAlexW2049529738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.