ArticleMolecular plant pathology2015
Cyclic lipopeptides from Bacillus subtilis activate distinct patterns of defence responses in grapevine.
Article in Molecular plant pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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74 citing papers in PubMed, 157 citations in OpenAlex.
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- Rhizosphere triangular warfare: mechanistic insights for plant- beneficial microbe- pathogen interactions.Frontiers in plant science · 2026Review
- Mechanism of action of a bactericidal lipopeptide which targets lipopolysaccharides of the plant pathogenFrontiers in plant science · 2026Article
- Bacillus velezensis Bac-9, isolated from kefir, possesses antifungal activity and improves resistance of tomato plant against whitefly Bemisia tabaci.BMC microbiology · 2025Article
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- Bacterial Cyclic Lipopeptides as Triggers of Plant Immunity and Systemic Resistance Against Pathogens.Plants (Basel, Switzerland) · 2025Review
- Surfactin acceleratesBiofilm · 2025Article
- Plipastatin is a shared good by Bacillus subtilis during combating Fusarium spp.FEMS microbiology ecology · 2025Article
- Biosynthesis and yield improvement strategies of fengycin.Archives of microbiology · 2025Review
- Diversification of Lipopeptide Analogues Drives Versatility in Biological Activities.Journal of agricultural and food chemistry · 2025Article
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- Antifungal potential of lipopeptides produced by theMicrobiology spectrum · 2024Article
- Comprehensive genomic analysis of Bacillus subtilis and Bacillus paralicheniformis associated with the pearl millet panicle reveals their antimicrobial potential against important plant pathogens.BMC plant biology · 2024Article
- Depletion of protective microbiota promotes the incidence of fruit disease.The ISME journal · 2024Article
- In Vitro Studies of Endophytic Bacteria Isolated from Ginger (Plants (Basel, Switzerland) · 2023Article
- Isolation and Identification of Endophytic BacteriaBiology · 2023Article
- Cyclic Lipopeptides ofJournal of fungi (Basel, Switzerland) · 2023Article
- Additive Effect of the Composition of Endophytic BacteriaLife (Basel, Switzerland) · 2023Article
- Metabolites fromPlants (Basel, Switzerland) · 2022Article
14 more citing papers are in PubMed but not listed here.
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10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-self-recognition of microorganisms partly relies on the perception of microbe-associated molecular patterns (MAMPs) and leads to the activation of an innate immune response. Bacillus subtilis produces three main families of cyclic lipopeptides (LPs), namely surfactins, iturins and fengycins. Although LPs are involved in induced systemic resistance (ISR) activation, little is known about defence responses induced by these molecules and their involvement in local resistance to fungi. Here, we showed that purified surfactin, mycosubtilin (iturin family) and plipastatin (fengycin family) are perceived by grapevine plant cells. Although surfactin and mycosubtilin stimulated grapevine innate immune responses, they differentially activated early signalling pathways and defence gene expression. By contrast, plipastatin perception by grapevine cells only resulted in early signalling activation. Gene expression analysis suggested that mycosubtilin activated salicylic acid (SA) and jasmonic acid (JA) signalling pathways, whereas surfactin mainly induced an SA-regulated response. Although mycosubtilin and plipastatin displayed direct antifungal activity, only surfactin and mycosubtilin treatments resulted in a local long-lasting enhanced tolerance to the necrotrophic fungus Botrytis cinerea in grapevine leaves. Moreover, challenge with specific strains overproducing surfactin and mycosubtilin led to a slightly enhanced stimulation of the defence response compared with the LP-non-producing strain of B. subtilis. Altogether, our results provide the first comprehensive view of the involvement of LPs from B. subtilis in grapevine plant defence and local resistance against the necrotrophic pathogen Bo. cinerea. Moreover, this work is the first to highlight the ability of mycosubtilin to trigger an immune response in plants.
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