ArticleClinical endocrinology2015
Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females.
Article in Clinical endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02725879 (Association of Serum Fibroblast Growth Factor 21), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association of Serum Fibroblast Growth Factor 21 (FGF-21) Levels With Resting Metabolic Rate (RMR), in Children and Adolescents With Hashimoto's Thyroiditis.
Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Hepatic lipogenesis marked by GCKR-modulated triglycerides increases serum FGF21 in children/teens with obesity.Diabetes, obesity & metabolism · 2025Article
- Relationship Between the Serum FGF21 Level and Growth in Children of Short Stature.Journal of Korean medical science · 2023Article
- Weight gain during the menopause transition: Evidence for a mechanism dependent on protein leverage.BJOG : an international journal of obstetrics and gynaecology · 2023Article
- Fibroblast Growth Factor 21 Levels and Bone Mineral Density in Metabolically Healthy and Metabolically Unhealthy Obese ChildrenJournal of clinical research in pediatric endocrinology · 2022Article
- Serum levels of the cold stress hormones FGF21 and GDF-15 after cardiac arrest in infants and children enrolled in single center therapeutic hypothermia clinical trials.Resuscitation · 2022Article
- Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly.Journal of the Endocrine Society · 2020Article
- Fibroblast Growth Factor 21, Adiponectin, and Irisin as Markers of Unfavorable Metabolic Features in 12-Year-Old Children.Journal of the Endocrine Society · 2019Article
- FGF-21 levels in polyuria-polydipsia syndrome.Endocrine connections · 2018Article
- Serum FGF21 Levels in Obese Korean Children and Adolescents.Journal of obesity & metabolic syndrome · 2017Article
- The alterations of serum FGF-21 levels, metabolic and body composition in early breast cancer patients receiving adjuvant endocrine therapy.Cancer biomarkers : section A of Disease markers · 2017Article
- Bone Mineral Content as a Driver of Energy Expenditure in Prepubertal and Early Pubertal Boys.The Journal of pediatrics · 2015Observational
- Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals.Journal of clinical & translational endocrinology · 2015Article
- Circulating FGF19 and FGF21 surge in early infancy from infra- to supra-adult concentrations.International journal of obesity (2005) · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAccumulating evidence derived primarily from animal models suggests that fibroblast growth factor-21 (FGF-21) may affect the musculoskeletal system via effects on the capacity of tissues to respond to insulin. A proportion of musculoskeletal properties and underpinnings of promoting/preventing insulin resistance are established early in the pubertal transition. Thus, the objective of this study was to test the hypothesis that insulin resistance and/or obesity will promote greater FGF-21 concentration which will be inversely associated with musculoskeletal parameters [lean mass and bone mineral content (BMC)] in pre-/early pubertal children. Given the sexual dimorphic nature of musculoskeletal development of fat mass accrual, differences by obesity status and sex were also investigated.
designCross-sectional. PATIENTS: Children ages 7-12 years (n = 69, 38% male, 48% non-Hispanic black, 45% obese). MEASUREMENTS: Fasting FGF-21, glucose and insulin measures were obtained. An estimate of insulin resistance was derived using the homoeostatic model assessment of insulin resistance (HOMA-IR). Body composition (BMC, lean mass and fat mass) was assessed by DXA. Multivariate regression analysis was used to evaluate the influence of FGF-21 on BMC, lean mass and HOMA-IR as dependent variables. Obesity status was established based on BMI z-score.
resultsFGF-21 concentrations did not differ by obesity status or by sex. There was an inverse association between FGF-21 and BMC among nonobese individuals (P = 0·01) and an inverse association between FGF-21 and lean mass among females (P = 0·02), which were both independent of fat mass. FGF-21 was inversely associated with HOMA-IR in males, but not females (P = 0·04).
conclusionsThe existence of relationships of FGF-21 with musculoskeletal parameters and insulin resistance raises the possibility of crosstalk between these systems. These findings suggest that circulating FGF-21 may differ in its association with bone, lean mass and insulin resistance depending on sex and weight status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.