ArticleJournal of experimental botany2014
Cucumber metal transport protein MTP8 confers increased tolerance to manganese when expressed in yeast and Arabidopsis thaliana.
Article in Journal of experimental botany, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Transcriptome-based analysis reveals key molecular mechanisms and functional characterization of MaCAX3 gene involved in manganese stress responses in mulberry plants.BMC plant biology · 2025Article
- Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration.Frontiers in plant science · 2025Review
- Regulatory Mechanism through Which Old Soybean Leaves Respond to Mn Toxicity Stress.International journal of molecular sciences · 2024Article
- Transcriptome Sequencing Analysis of Root in Soybean Responding to Mn Poisoning.International journal of molecular sciences · 2023Article
- Comparative Transcriptome Analysis Reveals Complex Physiological Response and Gene Regulation in Peanut Roots and Leaves under Manganese Toxicity Stress.International journal of molecular sciences · 2023Article
- MTP8 fromInternational journal of molecular sciences · 2022Article
- Identification and evolutionary analysis of the metal-tolerance protein family in eight Cucurbitaceae species.The plant genome · 2022Article
- Comprehensive genome wide identification and expression analysis ofSaudi journal of biological sciences · 2021Article
- Comparative and Systematic Omics Revealed Low Cd Accumulation of PotatoInternational journal of molecular sciences · 2021Article
- Strategies in a metallophyte species to cope with manganese excess.Environmental geochemistry and health · 2021Article
- Characterization of Metal Tolerance Proteins and Functional Analysis of GmMTP8.1 Involved in Manganese Tolerance in Soybean.Frontiers in plant science · 2021Article
- Genome-Wide Identification and Expression Analysis of Metal Tolerance Protein Gene Family inFrontiers in genetics · 2021Article
- Physiological and transcriptomic analyses reveal the roles of secondary metabolism in the adaptive responses of Stylosanthes to manganese toxicity.BMC genomics · 2020Article
- Genome-Wide Identification of Metal Tolerance Protein Genes inInternational journal of molecular sciences · 2020Article
- Reducing Cadmium Accumulation in Plants: Structure-Function Relations and Tissue-Specific Operation of Transporters in the Spotlight.Plants (Basel, Switzerland) · 2020Review
- Advances in the Mechanisms of Plant Tolerance to Manganese Toxicity.International journal of molecular sciences · 2019Review
- Recent Trends in Enhancing the Resistance of Cultivated Plants to Heavy Metal Stress by Transgenesis and Transcriptional Programming.Molecular biotechnology · 2019Review
- Metal tolerance protein MTP6 affects mitochondrial iron and manganese homeostasis in cucumber.Journal of experimental botany · 2019Article
- Genome-Wide Identification, Comprehensive Gene Feature, Evolution, and Expression Analysis of Plant Metal Tolerance Proteins in Tobacco Under Heavy Metal Toxicity.Frontiers in genetics · 2019Article
- A cation diffusion facilitator, GmCDF1, negatively regulates salt tolerance in soybean.PLoS genetics · 2019Article
Corrections and comments
- Retraction · 2020-01-23Duplication of/in Article · Manipulation of Images ·
- Retracted
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cation diffusion facilitator (CDF) proteins are ubiquitous divalent cation transporters that have been proved to be essential for metal homeostasis and tolerance in Archaebacteria, Bacteria, and Eukaryota. In plants, CDFs are designated as metal tolerance proteins (MTPs). Due to the lack of genomic resources, studies on MTPs in other plants, including cultivated crops, are lacking. Here, the identification and organization of genes encoding members of the MTP family in cucumber are described. The first functional characterization of a cucumber gene encoding a member of the Mn-CDF subgroup of CDF proteins, designated as CsMTP8 based on the highest homology to plant MTP8, is also presented. The expression of CsMTP8 in Saccharomyces cerevisiae led to increased Mn accumulation in yeast cells and fully restored the growth of mutants hypersensitive to Mn in Mn excess. Similarly, the overexpression of CsMTP8 in Arabidopsis thaliana enhanced plant tolerance to high Mn in nutrition media as well as the accumulation of Mn in plant tissues. When fused to green fluorescent protein (GFP), CsMTP8 localized to the vacuolar membranes in yeast cells and to Arabidopsis protoplasts. In cucumber, CsMTP8 was expressed almost exclusively in roots, and the level of gene transcript was markedly up-regulated or reduced under elevated Mn or Mn deficiency, respectively. Taken together, the results suggest that CsMTP8 is an Mn transporter localized in the vacuolar membrane, which participates in the maintenance of Mn homeostasis in cucumber root cells.
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