Evidence map›Paper›PMID 25039043›Full record

ArticleThe Journal of pediatrics2014

Lipoprotein particle concentrations in children and adults following Kawasaki disease.

Jonathan Lin, Sonia Jain, Xiaoying Sun, Victoria Liu, Yuichiro Z Sato, Susan Jimenez-Fernandez, Ron S Newfield, Ray Pourfarzib, Adriana H Tremoulet, John B Gordon and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. An Update on Cardiovascular Risk Factors After Kawasaki Disease.Frontiers in cardiovascular medicine · 2021
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jonathan LinDepartment of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
Sonia JainDivision of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA.
Xiaoying SunDivision of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA.
Victoria LiuDepartment of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
Yuichiro Z SatoDepartment of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
Susan Jimenez-FernandezDepartment of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
Ron S NewfieldDepartment of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
Ray PourfarzibDepartment of Medical Affairs, LipoScience, Inc, Raleigh, NC.
Adriana H TremouletDepartment of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
John B GordonSharp Memorial Hospital and San Diego Cardiac Center, San Diego, CA.
Lori B DanielsDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA.
Jane C BurnsDepartment of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA. Electronic address: jcburns@ucsd.edu.
University of California San Diego · USSharp Memorial Hospital · US

Funding

iDASH: Integrating Data for Analysis, Anonymization, and SharingU54HL108460 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OHNO-MACHADO, LUCILA · 2010 to 2015
$19.1M
Genetic Markers and gene expression in Kawasaki DiseaseR01HL069413 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURNS, JANE C · 2002 to 2010
$5.5M
T35 Short Term Research Training GrantT35HL007491 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAVOIA, MARIA CHRISTINA · 1985 to 2015
$2.8M
NHLBI NIH HHS R01 HL069413NHLBI NIH HHS R01-HL69413NHLBI NIH HHS T35 HL007491NHLBI NIH HHS U54 HL108460
6 · The paper itself

Abstract

objectiveTo test the hypothesis that children and adults with a history of Kawasaki disease (KD) are more likely to have abnormal lipoprotein particle profiles that could place them at increased risk for developing atherosclerosis later in life. STUDY

designFasting serum samples were obtained from 192 children and 63 adults with history of KD and 90 age-similar healthy controls. Lipoprotein particle concentrations and sizes were measured by nuclear magnetic resonance spectroscopy (LipoScience Inc, Raleigh, North Carolina), and serum was assayed for total cholesterol (TC), triglycerides, and high-density lipoprotein (HDL) cholesterol (HDL-C). Low-density lipoprotein (LDL) cholesterol was estimated using the Friedewald formula. Data were analyzed in a least-square means model, with adjustment for age and sex and with the use of Holm correction for multiple comparisons.

resultsCompared with respective control groups, both adult and pediatric subjects with KD had significantly lower mean very low-density lipoprotein-chylomicron particles, intermediate-density lipoproteins, triglycerides, and TC concentrations. Pediatric subjects with KD had significantly lower LDL particle and LDL cholesterol concentrations and lower mean TC/HDL-C ratio (P < .001). In contrast, the adult subjects with KD had significantly lower HDL particle, small HDL particle, and HDL-C concentrations (P < .001), but HDL-C was within normal range.

conclusionsNuclear magnetic resonance lipoprotein particle analysis suggests that pediatric and adult subjects with KD, regardless of their aneurysm status, are no more likely than age-similar, healthy controls to have lipid patterns associated with increased risk of atherosclerosis.

Indexed as

AdolescentAdultAtherosclerosisBody Mass IndexCase-Control StudiesChildChild, PreschoolCholesterol, HDLCholesterol, LDLChylomicronsFemaleFollow-Up StudiesHumansLipoproteinsMagnetic Resonance SpectroscopyMaleCholesterol, HDLCholesterol, LDLChylomicronsLipoproteins

Identifiers

PMID25039043
PMCPMC4207833
OpenAlexW1967933476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.